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Principal stratification (PS) is a commonly used approach for understanding the mechanisms through which a treatment affects an outcome. The goal of this work is to extend the PS framework to studies with continuous treatments, which introduces a number of both challenges and opportunities in terms of defining causal effects and performing inference. This manuscript provides multiple key methodological contributions: 1) we introduce principal causal estimands for continuous…

多中介情形下自然直接与间接相对风险的回归方法AI 解读

Mediation analysis investigates whether part of the treatment effect is channelled through one or more mediators along the causal pathway between the treatment and the primary outcome. However, the presence of multiple, potentially dependent mediators raises substantial challenges, particularly when the outcome is binary, the mediators are measured on different scales, and interactions are present. We consider on causal mediation analysis with a binary treatment and a binary…

空间面板数据的空间纵向回归：佛罗伦萨首条电车线对商业活力的影响AI 解读

Synthetic control methods are commonly used in panel data settings to evaluate the effect of an intervention. In many of these cases, the treated and control units correspond to spatial units such as regions or neighborhoods. Our approach addresses the challenge of understanding how an intervention applied at specific locations influences the surrounding area. Traditional synthetic control applications may struggle with defining the effective area of impact, the extent of…

存在治疗中止的肿瘤随机试验中事件时间结局的因果效应评估AI 解读

In clinical trials, patients may discontinue treatments prematurely, breaking the initial randomization and, thus, challenging inference. Stakeholders in drug development are generally interested in going beyond the Intention-To-Treat (ITT) analysis, which provides valid causal estimates of the effect of treatment assignment but does not inform on the effect of the actual treatment receipt. Our study is motivated by an RCT in oncology, where patients assigned the…

断点回归设计中因果推断子总体的选择AI 解读

The Brazil Bolsa Familia (BF) program is a conditional cash transfer program aimed to reduce short-term poverty by direct cash transfers and to fight long-term poverty by increasing human capital among poor Brazilian people. Eligibility for Bolsa Familia benefits depends on a cutoff rule, which classifies the BF study as a regression discontinuity (RD) design. Extracting causal information from RD studies is challenging. Following Li et al (2015) and Branson and Mealli…

纵向数据与死亡截断下的贝叶斯主分层AI 解读

In many causal studies, outcomes are censored by death, in the sense that they are neither observed nor defined for units who die. In such studies, the focus is usually on the stratum of always survivors up to a single fixed time s. Building on a recent strand of the literature, we propose an extended framework for the analysis of longitudinal studies, where units can die at different time points, and the main endpoints are observed and well defined only up to the death…