Matched Design for Marginal Causal Effect on Restricted Mean Survival Time in Observational Studies
观察性研究中限制平均生存时间边际因果效应的匹配设计
Investigating the causal relationship between exposure and the time-to-event outcome is an important topic in biomedical research. Previous literature has discussed the potential issues of using the hazard ratio as a marginal causal effect measure due to its noncollapsibility property. In this paper, we advocate using the restricted mean survival time (RMST) difference as the marginal causal effect measure, which is collapsible and has a simple interpretation as the…