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生存结局未观测混杂的双重有效、双重锐利敏感性分析AI 解读

Time-to-event outcomes are central in oncology and rare diseases, where treatment effects are often summarized by differences in survival curves or Restricted Mean Survival Time (RMST). In real-world data, estimating these causal effects relies on the absence of unobserved confounding, an assumption that is rarely satisfied. We develop a sensitivity analysis framework for causal treatment effects with survival outcomes under the Marginal Sensitivity Model (MSM). We introduce…

加权估计敏感性模型中混杂强度的校准：比较综述与新方法AI 解读

Causal inference is only valid when its underlying assumptions are satisfied, one of the most central being the ignorability or unconfoundedness assumption. However, this hypothesis is often unrealistic in observational studies, as some confounding variables may remain unobserved. To address this limitation, sensitivity models for Inverse Probability Weighting (IPW) estimators, known as Marginal Sensitivity Models, have been introduced, allowing for a controlled relaxation…

存在未观测混杂时连续处理效应的锐界AI 解读

In causal inference, treatment effects are typically estimated under the ignorability, or unconfoundedness, assumption, which is often unrealistic in observational data. By relaxing this assumption and conducting a sensitivity analysis, we introduce novel bounds and derive confidence intervals for the Average Potential Outcome (APO) - a standard metric for evaluating continuous-valued treatment or exposure effects. We demonstrate that these bounds are sharp under a…

存在时变混杂因素时的已处理者平均处理效应去偏估计AI 解读

With the increased availability of large health databases comes the opportunity of evaluating treatment effect on new data sources.Through these databases time-dependent outcomes can be analysed as events that can be measured using counting processes. Estimating average treatment effect on the treated (ATT) requires modelling of time-varying covariate and time-dependent treatment and outcome. Gran et al. proposed an easy-to-implement method based on additive intensity…

SurvCaus：生存因果推断中的表征平衡AI 解读

Individual Treatment Effects (ITE) estimation methods have risen in popularity in the last years. Most of the time, individual effects are better presented as Conditional Average Treatment Effects (CATE). Recently, representation balancing techniques have gained considerable momentum in causal inference from observational data, still limited to continuous (and binary) outcomes. However, in numerous pathologies, the outcome of interest is a (possibly censored) survival time.…