A flexible Bayesian g-formula for causal survival analyses with time-dependent confounding
处理时变混杂的灵活贝叶斯生存分析 g 公式AI 解读 ↓
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处理时变混杂的灵活贝叶斯生存分析 g 公式AI 解读 ↓
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In longitudinal observational studies with time-to-event outcomes, a common objective in causal analysis is to estimate the causal survival curve under hypothetical intervention scenarios. The g-formula is a useful tool for this analysis. To enhance the traditional parametric g-formula, we developed an alternative g-formula estimator, which incorporates the Bayesian Additive Regression Trees (BART) into the modeling of the time-evolving generative components, aiming to mitigate the bias due to model misspecification. We focus on binary time-varying treatments and introduce a general class of g-formulas for discrete survival data that can incorporate the longitudinal balancing scores. The minimum sufficient formulation of these longitudinal balancing scores is linked to the nature of treatment strategies, i.e., static or dynamic. For each type of treatment strategy, we provide posterior sampling algorithms. We conducted simulations to illustrate the empirical performance of the proposed method and demonstrate its practical utility using data from the Yale New Haven Health System's electronic health records.
用贝叶斯决策树集成估计异质性因果中介效应
The causal inference literature has increasingly recognized that targeting treatment effect heterogeneity can lead to improved scientific understanding and policy recommendations. Similarly, studying the causal pathway connecting the treatment to the outcome can be useful. We address these problems in the context of causal mediation analysis . We introduce a varying coefficient model based on Bayesian additive regression trees to estimate and regularize heterogeneous causal…
纵向中介与事件时间结局的贝叶斯半参数因果中介分析
Causal mediation analysis of observational data is an important tool for investigating the potential causal effects of medications on disease-related risk factors, and on time-to-death (or disease progression) through these risk factors. However, when analyzing data from a cohort study, such analyses are complicated by the longitudinal structure of the risk factors and the presence of time-varying confounders. Leveraging data from the Atherosclerosis Risk in Communities…
利用贝叶斯决策树集成估计异质性因果中介效应
The causal inference literature has increasingly recognized that explicitly targeting treatment effect heterogeneity can lead to improved scientific understanding and policy recommendations. Towards the same ends, studying the causal pathway connecting the treatment to the outcome can be also useful. This paper addresses these problems in the context of \emph{causal mediation analysis}. We introduce a varying coefficient model based on Bayesian additive regression trees to…
基于双重/去偏机器学习的时变连续处理双重差分
We propose a difference-in-differences (DiD) framework designed for time-varying continuous treatments across multiple periods. Specifically, we estimate the average treatment effect on the treated (ATET) by comparing distinct non-zero treatment intensities. Identification rests on a conditional parallel trends assumption that accounts for observed covariates and past treatment histories. Our approach allows for lagged treatment effects and, in repeated cross-sectional…
密集纵向数据的动态因果中介分析
Intensive longitudinal data, characterized by frequent measurements across numerous time points, are increasingly common due to advances in wearable devices and mobile health technologies. We consider evaluating causal mediation pathways between time-varying exposures, time-varying mediators, and a final, distal outcome using such data. Addressing mediation questions in these settings is challenging due to numerous potential exposures, complex mediation pathways, and…
用于双重差分的森林:超越参数模型的因果推断
This paper introduces the Difference-in-Differences Bayesian Causal Forest (DiD-BCF), a novel non-parametric model addressing key challenges in DiD estimation, such as staggered adoption and heterogeneous treatment effects. DiD-BCF provides a unified framework for estimating Average (ATE), Group-Average (GATE), and Conditional Average Treatment Effects (CATE). A core innovation, its Parallel Trends Assumption (PTA)-based reparameterization, enhances estimation accuracy and…