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AI 根据所提供的论文材料归类:摘要明确研究边际因果效应、连续暴露的混杂控制,以及纵向个体数据中受协变量影响的随访机制。

反馈分类问题

Estimating the Marginal Effect of a Continuous Exposure on an Ordinal Outcome using Data Subject to Covariate-Driven Treatment and Visit Processes

协变量驱动暴露与随访下连续暴露对有序结局的边际效应估计

正在核对关联版本…

代码、数据与补充材料

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关注这篇论文的作者
Janie Coulombe
Erica E M Moodie
Robert W Platt

协变量驱动暴露与随访下连续暴露对有序结局的边际效应估计

研究问题
当连续暴露和纵向随访时间均受协变量影响时,如何同时处理混杂与不规则观测偏差,估计连续暴露对有序结局的边际因果效应?
方法与思路
作者用比例优势模型描述有序结局、比例率模型处理不规则观测时间,并推广逆概率处理权重以适应连续暴露,辅以模拟和应用。
材料陈述的贡献
摘要提出同时处理暴露与观测机制的方法,并称模拟表明忽略两类机制造成的不平衡可能使暴露的边际优势比估计产生偏差。
阅读关注点
应核对暴露及观测机制的识别条件、权重构造与模型设定,并区分实际应用的预设随访时间和模拟中的个体间不规则观测。
阅读边界
这是 arXiv 预印本,同行评审或期刊接收未核实。摘要未列出完整识别条件和数值结果,实际应用并未直接覆盖高度不规则随访。

原文摘要

In the statistical literature, a number of methods have been proposed to ensure valid inference about marginal effects of variables on a longitudinal outcome in settings with irregular monitoring times. However, the potential biases due to covariate-driven monitoring times and confounding have rarely been considered simultaneously, and never in a setting with an ordinal outcome and a continuous exposure. In this work, we propose and demonstrate a methodology for causal inference in such a setting, relying on a proportional odds model to study the effect of the exposure on the outcome. Irregular observation times are considered via a proportional rate model, and a generalization of inverse probability of treatment weights is used to account for the continuous exposure. We motivate our methodology by the estimation of the marginal (causal) effect of the time spent on video or computer games on suicide attempts in the Add Health study, a longitudinal study in the United States. Although in the Add Health data, observation times are pre-specified, our proposed approach is applicable even in more general settings such as when analyzing data from electronic health records where observations are highly irregular. In simulation studies, we let observation times vary across individuals and demonstrate that not accounting for biasing imbalances due to the monitoring and the exposure schemes can bias the estimate for the marginal odds ratio of exposure.

笔记与分组
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