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本页整理公开书目信息,不生成学术质量评分。AI 解读根据题名及所注明的摘要或原文片段生成,未完成全文核验,可能有误;具体假设、证明与结论请核对原文。摘要保留来源文本,未经模型改写。

DOI 首次登记不等于接收或发表日期。部分更正、评论等条目没有独立摘要;缺少可靠材料时保留待补状态。

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分类依据与纠错

AI 根据所提供的论文材料归类:摘要针对基因组高维稀疏回归,未提供所列经济或金融细分的直接依据。

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关注这篇论文的作者
Priyam Das

面向超高维数据的贝叶斯单变量引导稀疏回归

研究问题
在包含数十万以上预测变量的基因组回归中,如何同时恢复稀疏信号、减少虚假发现并降低贝叶斯计算成本?
方法与思路
作者将边际关联信息连续嵌入正则化马蹄先验的收缩结构,并提出活动集 MCMC 近似以减少局部尺度更新。
材料陈述的贡献
摘要称,方法具有先验集中和后验收缩等理论结果,模拟中经验虚假发现率较低,甲基化应用无需预筛选。
阅读关注点
应核对边际引导信息的来源与数据复用处理、活动集近似误差,以及相关设计下信号恢复和虚假发现的定义。
阅读边界
依据 arXiv v3 预印本摘要,不能据此声称已同行评审或接收;经验虚假发现率较低不等于一般性的错误率控制。

原文摘要

Ultra-high-dimensional genomic studies require simultaneous identification of sparse signals, control of spurious discoveries, and computationally feasible inference when the number of predictors can reach hundreds of thousands or more. We propose Bayesian Univariate-Guided Sparse Regression (BUGS), a global--local shrinkage framework that incorporates marginal association information directly into the prior through continuous modulation of shrinkage. By embedding univariate guidance within the nonlinear variance structure of a regularized horseshoe prior, BUGS adaptively differentiates predictors with strong and weak marginal evidence without relying on hard screening. We establish theoretical results on prior concentration, posterior contraction, and guidance-induced shrinkage separation, and characterize the behavior of the prior under uninformative guidance. For ultra-high-dimensional problems, we develop BUGS-Active, an active-set MCMC approximation that reduces the cost of local-scale updates from $O(p)$ to $O(|A_n|)$ while retaining global coefficient updates. Simulations under independent and correlated designs show strong signal recovery and substantially lower empirical false discovery rates relative to competing methods. We apply BUGS-Active to a DNA methylation study of developmental age with $n=1051$ samples and approximately $850{,}000$ CpG sites, jointly analyzing all probes without pre-screening. The analysis yields strong out-of-sample prediction and a sparse set of age-associated CpG sites with stable posterior support. These results illustrate the practical value of marginally guided Bayesian shrinkage for large-scale genomic regression.

笔记与分组