Extreme Treatment Effect: Extrapolating Dose-Response Function Into Extreme Treatment Domain
极端处理效应:向极端处理范围外推剂量反应函数AI 解读 ↓
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极端处理效应:向极端处理范围外推剂量反应函数AI 解读 ↓
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The potential outcomes framework serves as a fundamental tool for quantifying causal effects. The average dose-response function (also called the effect curve), denoted as (μ(t)), is typically of interest when dealing with a continuous treatment variable (exposure). The focus of this work is to determine the impact of an extreme level of treatment, potentially beyond the range of observed values--that is, estimating (μ(t)) for very large (t). Our approach is grounded in the field of statistics known as extreme value theory. We outline key assumptions for the identifiability of the extreme treatment effect. Additionally, we present a novel and consistent estimation procedure that can potentially reduce the dimension of the confounders to at most 3. This is a significant result since typically, the estimation of (μ(t)) is very challenging due to high-dimensional confounders. In practical applications, our framework proves valuable when assessing the effects of scenarios such as drug overdoses, extreme river discharges, or extremely high temperatures on a variable of interest.
IV-LASSO 的工具变量字典与惩罚选择
Estimating the first stage of an instrumental variables (IV) model with the least absolute shrinkage and selection operator (LASSO) requires choosing a dictionary of technical instruments and a penalty level. First-order asymptotic theory offers no guidance on these choices, as any consistent implementation yields a structural parameter estimator with the same limiting distribution. In finite samples, however, these choices can have a substantial impact on the resulting…
嵌套工具变量分析:转换者平均处理效应及可推广性
Instrumental variables (IVs) are widely used to estimate causal effects from non-randomized data. A canonical example is a randomized trial with noncompliance, in which the randomized treatment assignment serves as an IV for the non-ignorable treatment received. Under a monotonicity assumption, a valid IV nonparametrically identifies the average treatment effect among a latent complier subgroup, whose generalizability is often under debate. In many studies, there exist…
This paper presents a causal decision framework for list-price elasticities in intermediated retail channels, where estimates are confounded by promotions, competitor moves and shopkeeper pass-through. Rather than forcing a number when the evidence is ambiguous, the system treats abstention (Wait) as an active diagnostic output. Built on Double Machine Learning and conformal prediction, it evaluates whether conditions exist to act on a recommended price or whether…
自删失模型下信息性缺失的纵向因果推断
Longitudinal observational data are often subject to informative missingness. For example, in healthcare research using electronic health records, covariates and outcomes are measured only when patients interact with the healthcare system. Whether these data are observed usually depends on the unobserved variable values themselves, introducing a common form of data missing not at random. We develop identification and estimation methods for the effects of longitudinal…
Comparing dependence structures between two related multivariate time series is of fundamental interest in many scientific applications, where changes may occur in both directed temporal interactions and contemporaneous connectivity. Modeling each time series by a vector autoregressive (VAR) model, we propose a new framework for estimation and inference of differential Granger causality (DiffGC) and differential network (DiffNet) structures in high dimensions. The proposed…
前门模型下因果效应的灵活非参数推断
Abstract Evaluating causal treatment effects in observational studies requires addressing confounding. While the back-door criterion enables identification through adjustment for observed covariates, it fails in the presence of unmeasured confounding. The front-door criterion offers an alternative by leveraging variables that fully mediate the treatment effect and are unaffected by unmeasured confounders of the treatment-outcome pair. We develop novel one-step and targeted…