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Heather Battey’s contribution to the Discussion of ‘Parameterizing and simulating from causal models’ by Evans and Didelez

Heather Battey对《因果模型的参数化与模拟》的讨论评论

My brief comment relates to the inferential discussion of Section 5. The sample-space factorization of the joint probability from the marginal structural model induces a parameter-space factorization of the likelihood function, with the implication that θZX is orthogonal to (⁠θY|X*,ϕYZ|X*⁠) in the sense of, e.g. Cox and Reid (1987), and leading to the simplified asymptotic covariance matrix of Theorem 5.1. The parameter cut discussed at the beginning of Section 5 also…

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Richard Guo’s contribution to the Discussion of ‘Parameterizing and simulating from causal models’ by Evans and Didelez

Richard Guo 对《因果模型的参数化与模拟》的讨论:两种分解与密度比

I congratulate Evans and Didelez warmly on this innovative and inspiring paper. Here, I offer my interpretation of the approach in terms of two factorizations and a density ratio. Any distribution over Z,X,Y can be factorized in two ways: Factorization C−1 is the usual one; it is factorization A−1 that is the focus of the two authors. More concretely, suppose ϕZY∣X(z,y∣x) is a conditional copula density, i.e. for every value of x, (z,y)↦ϕZY∣X(z,y∣x) is a density function…

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Torben Martinussen’s contribution to the Discussion of ‘Parameterizing and simulating from causal models’ by Evans and Didelez

马丁努森对《因果模型的参数化与模拟》的讨论

I congratulate the authors on an interesting and useful contribution to the literature on causal inference. The authors propose a nice way of generating data so that a given causal structure of interest is preserved. This is a handy tool to have when for instance one needs to generate data to investigate small sample performance of a new inference procedure. I find it less attractive to use the suggested procedure for estimation purposes as is also alluded to in the paper…

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A. Philip Dawid’s contribution to the Discussion of ‘Parameterizing and simulating from causal models’ by Evans and Didelez

A. Philip Dawid对《因果模型的参数化与模拟》的讨论意见

When discussing causal inference in sequential problems, the authors only consider interventions that set their target variables to pre-specified fixed values. A more practically relevant aim, as considered by Dawid and Didelez (2010), is to assess the effect of a pre-specified dynamic treatment strategy, which details how each decision is to depend (possibly even stochastically) on previously observed variables. Can the methods of this paper be applied to this case?

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Estimating a directed tree for extremes

从极端数据估计指向根节点的有向树

Abstract We propose a new method to estimate a root-directed spanning tree from extreme data. Prominent example is a river network, to be discovered from extreme flow measured at a set of stations. Our new algorithm utilizes qualitative aspects of a max-linear Bayesian network, which has been designed for modelling causality in extremes. The algorithm estimates bivariate scores and returns a root-directed spanning tree. It performs extremely well on benchmark data and on new…

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Semi-parametric tensor factor analysis by iteratively projected singular value decomposition

通过迭代投影奇异值分解进行半参数张量因子分析

Abstract This paper introduces a general framework of Semi-parametric TEnsor Factor Analysis (STEFA) that focuses on the methodology and theory of low-rank tensor decomposition with auxiliary covariates. Semi-parametric TEnsor Factor Analysis models extend tensor factor models by incorporating auxiliary covariates in the loading matrices. We propose an algorithm of iteratively projected singular value decomposition (IP-SVD) for the semi-parametric estimation. It iteratively…

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Gradient synchronization for multivariate functional data, with application to brain connectivity

多元函数型数据的梯度同步性及脑连接应用

Abstract Quantifying the association between components of multivariate random curves is of general interest and is a ubiquitous and basic problem that can be addressed with functional data analysis. An important application is the problem of assessing functional connectivity based on functional magnetic resonance imaging (fMRI), where one aims to determine the similarity of fMRI time courses that are recorded on anatomically separated brain regions. In the functional brain…

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Integrative conformal p -values for out-of-distribution testing with labelled outliers

Abstract This paper presents a conformal inference method for out-of-distribution testing that leverages side information from labelled outliers, which are commonly underutilized or even discarded by conventional conformal p-values. This solution is practical and blends inductive and transductive inference strategies to adaptively weight conformal p-values, while also automatically leveraging the most powerful model from a collection of one-class and binary classifiers.…

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Optimal individualized treatment rule for combination treatments under budget constraints

预算约束下组合治疗的最优个体化治疗规则

Abstract The individualized treatment rule (ITR), which recommends an optimal treatment based on individual characteristics, has drawn considerable interest from many areas such as precision medicine, personalized education, and personalized marketing. Existing ITR estimation methods mainly adopt 1 of 2 or more treatments. However, a combination of multiple treatments could be more powerful in various areas. In this paper, we propose a novel double encoder model (DEM) to…

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Policy evaluation for temporal and/or spatial dependent experiments

Abstract The aim of this article is to establish a causal link between the policies implemented by technology companies and the outcomes they yield within intricate temporal and/or spatial dependent experiments. We propose a novel temporal/spatio-temporal Varying Coefficient Decision Process model, capable of effectively capturing the evolving treatment effects in situations characterized by temporal and/or spatial dependence. Our methodology encompasses the decomposition of…

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Simultaneous directional inference

同时方向推断

Abstract We consider the problem of inference on the signs of n>1 parameters. We aim to provide 1−α post hoc confidence bounds on the number of positive and negative (or non-positive) parameters, with a simultaneous guarantee, for all subsets of parameters. We suggest to start by using the data to select the direction of the hypothesis test for each parameter; then, adjust the p-values of the one-sided hypotheses for the selection, and use the adjusted p-values for…

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The HulC: confidence regions from convex hulls

HulC:利用凸包构造置信区域

Abstract We develop and analyse the HulC, an intuitive and general method for constructing confidence sets using the convex hull of estimates constructed from subsets of the data. Unlike classical methods which are based on estimating the (limiting) distribution of an estimator, the HulC is often simpler to use and effectively bypasses this step. In comparison to the bootstrap, the HulC requires fewer regularity conditions and succeeds in many examples where the bootstrap…

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Parameterizing and simulating from causal models

因果模型的参数化与模拟

Abstract Many statistical problems in causal inference involve a probability distribution other than the one from which data are actually observed; as an additional complication, the object of interest is often a marginal quantity of this other probability distribution. This creates many practical complications for statistical inference, even where the problem is non-parametrically identified. In particular, it is difficult to perform likelihood-based inference, or even to…

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Reading the Candlesticks: An OK Estimator for Volatility

解读 K 线:即时波动率的 OK 估计量

Abstract We propose an Optimal candlesticK (OK) estimator for the spot volatility using high-frequency candlestick observations. Under a standard infill asymptotic setting, we show that the OK estimator is asymptotically unbiased and has minimal asymptotic variance within a class of linear estimators. Its estimation error can be coupled by a Brownian functional, which permits valid inference. Our theoretical and numerical results suggest that the proposed candlestick-based…

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Statistical Methods in Health Disparity Research

健康差异研究中的统计方法

In Statistical Methods in Health Disparity Research, author J. Sunil Rao invokes the U.S. Department of Health and Human Services’ Healthy People 2020 definition of health disparity, which is “a pa...

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Coexchangeable Process Modeling for Uncertainty Quantification in Joint Climate Reconstruction

联合气候重建不确定性量化的联合可交换过程模型

Any experiment with climate models relies on a potentially large set of spatio-temporal boundary conditions. These can represent both the initial state of the system and/or forcings driving the model output throughout the experiment. These boundary conditions are typically fixed using available reconstructions in climate modeling studies; however, in reality they are highly uncertain, that uncertainty is unquantified, and the effect on the output of the experiment can be…

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Tree-Guided Rare Feature Selection and Logic Aggregation with Electronic Health Records Data

电子健康记录中的树引导稀有特征选择与逻辑聚合

Statistical learning with a large number of rare binary features is commonly encountered in analyzing electronic health records (EHR) data, especially in the modeling of disease onset with prior medical diagnoses and procedures. Dealing with the resulting highly sparse and large-scale binary feature matrix is notoriously challenging as conventional methods may suffer from a lack of power in testing and inconsistency in model fitting, while machine learning methods may suffer…

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Latent Multimodal Functional Graphical Model Estimation

潜在多模态函数型图模型估计

Joint multimodal functional data acquisition, where functional data from multiple modes are measured simultaneously from the same subject, has emerged as an exciting modern approach enabled by recent engineering breakthroughs in the neurological and biological sciences. One prominent motivation to acquire such data is to enable new discoveries of the underlying connectivity by combining multimodal signals. Despite the scientific interest, there remains a gap in principled…

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Frequency Detection and Change Point Estimation for Time Series of Complex Oscillation

复杂振荡时间序列的频率检测与变点估计

We consider detecting the evolutionary oscillatory pattern of a signal when it is contaminated by nonstationary noises with complexly time-varying data generating mechanism. A high-dimensional dense progressive periodogram test is proposed to accurately detect all oscillatory frequencies. A further phase-adjusted local change point detection algorithm is applied in the frequency domain to detect the locations at which the oscillatory pattern changes. Our method is shown to…

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Evaluating Dynamic Conditional Quantile Treatment Effects with Applications in Ridesharing

动态条件分位数处理效应的评估及网约车应用

Many modern tech companies, such as Google, Uber, and Didi, utilize online experiments (also known as A/B testing) to evaluate new policies against existing ones. While most studies concentrate on average treatment effects, situations with skewed and heavy-tailed outcome distributions may benefit from alternative criteria, such as quantiles. However, assessing dynamic quantile treatment effects (QTE) remains a challenge, particularly when dealing with data from ride-sourcing…

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Assessing COVID-19 Prevalence in Austria with Infection Surveys and Case Count Data as Auxiliary Information

结合感染调查与病例计数辅助信息估计奥地利新冠感染率

Countries officially record the number of COVID-19 cases based on medical tests of a subset of the population. These case count data obviously suffer from participation bias, and for prevalence estimation, these data are typically discarded in favour of infection surveys, or possibly also completed with auxiliary information. One exception is the series of infection surveys recorded by the Statistics Austria Federal Institute to study the prevalence of COVID-19 in Austria in…

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Bayesian Integrative Region Segmentation in Spatially Resolved Transcriptomic Studies

空间转录组研究中的贝叶斯整合区域分割

The spatially resolved transcriptomic study is a recently developed biological experiment that can measure gene expressions and retain spatial information simultaneously, opening a new avenue to characterize fine-grained tissue structures. In this article, we propose a nonparametric Bayesian method named BINRES to carry out the region segmentation for a tissue section by integrating all the three types of data generated during the study—gene expressions, spatial coordinates,…

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A Unified Nonparametric Fiducial Approach to Interval-Censored Data

区间删失数据的统一非参数 fiducial 推断

Censored data, where the event time is partially observed, are challenging for survival probability estimation. In this article, we introduce a novel nonparametric fiducial approach to interval-censored data, including right-censored, current status, case II censored, and mixed case censored data. The proposed approach leveraging a simple Gibbs sampler has a useful property of being “one size fits all,” that is, the proposed approach automatically adapts to all types of…

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