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Harmonized estimation of subgroup-specific treatment effects in randomized trials: the use of external control data

利用外部对照数据协调随机试验的亚组处理效应估计

Abstract Subgroup analyses of randomized controlled trials (RCTs) constitute an important component of the drug development process in precision medicine. In particular, subgroup analyses of early-stage trials often influence the design and eligibility criteria of subsequent confirmatory trials and ultimately influence which subpopulations will receive the treatment after regulatory approval. However, subgroup analyses are often complicated by small sample sizes, which leads…

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Empirical likelihood for manifolds

流形数据的经验似然

Abstract There has been growing interest in statistical analysis of random objects taking values in a non-Euclidean metric space. One important class of such objects consists of data on manifolds. This article is concerned with inference on the Fréchet mean and related population objects on manifolds. We develop the concept of nonparametric likelihood for data on manifolds and propose general inference methods by adapting the theory of empirical likelihood. In addition to…

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Identification and multiply robust estimation in causal mediation analysis across principal strata

主分层因果中介分析的识别与多重稳健估计

Abstract We consider assessing causal mediation in the presence of a posttreatment event (examples include noncompliance, a clinical event, or death). We identify natural mediation effects for the entire study population and for each principal stratum characterized by the joint potential values of the posttreatment event. We derive the efficient influence function for each mediation estimand, which motivates a set of multiply robust estimators for inference. The multiply…

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Identification of Semiparametric Panel Multinomial Choice Models with Infinite-Dimensional Fixed Effects

具有无限维固定效应的半参数面板多项选择模型识别

Abstract This paper proposes a robust method for semiparametric identification and estimation in panel multinomial choice models, where we allow for infinite-dimensional fixed effects that enter into consumer utilities in an additively nonseparable way, thus incorporating rich forms of unobserved heterogeneity. Our identification strategy exploits multivariate monotonicity in parametric indices, and uses the logical contraposition of an intertemporal inequality on choice…

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Long Story Short: Omitted Variable Bias in Causal Machine Learning

Abstract We develop a general theory of omitted variable bias for a wide range of common causal parameters, including average treatment effects, average causal derivatives, and policy effects from covariate shifts. We show how plausibility judgments on the maximum explanatory power of omitted variables are sufficient to bound the bias, facilitating sensitivity analysis in otherwise complex models. Finally, we provide statistical inference methods that can leverage modern…

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Information theoretic limits of robust sub-Gaussian mean estimation under star-shaped constraints

星形约束下稳健次高斯均值估计的信息论极限

We obtain the minimax rate for a mean location model with a bounded star-shaped set K⊆Rn constraint on the mean, in an adversarially corrupted data setting with Gaussian noise. We assume an unknown fraction ϵ≤1/2−κ for some fixed κ∈(0,1/2] of N observations are arbitrarily corrupted. We obtain a minimax risk up to proportionality constants under the squared ℓ2 loss of max(η∗2,σ2ϵ2)∧d2 with η∗=sup{η≥0:Nη2 σ2≤logMKloc(η,c)}, where logMKloc(η,c) denotes the local entropy of the…

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Optimality of approximate message passing for spiked matrix models with rotationally invariant noise

旋转不变噪声尖峰矩阵模型中近似消息传递的最优性

We study the problem of estimating a rank-one signal matrix from a noisy observed matrix corrupted by additive rotationally invariant noise. We develop a new class of approximate message passing algorithms for this problem and provide a simple and concise characterization of their dynamics in the high-dimensional limit. At each iteration, these algorithms leverage prior knowledge about the noise structure by applying a nonlinear matrix denoiser to the eigenvalues of the…

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Communication-efficient and distributed-oracle estimation for high-dimensional quantile regression

高维分位数回归的通信高效估计与分布式预言机估计

In this article, we present a novel communication-efficient estimator for distributed high-dimensional quantile regression with folded-concave penalties. An Iterative Multi-Step Algorithm (IMSA) is employed to tackle the nonconvex challenge of the objective function, taking into account both the statistical accuracy and the communication constraints. We demonstrate that the proposed IMSA estimators share similar properties with the global folded-concave penalized estimator.…

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Optimal convex M-estimation via score matching

通过得分匹配实现最优凸 M 估计

In the context of linear regression, we construct a data-driven convex loss function with respect to which empirical risk minimisation yields optimal asymptotic variance in the downstream estimation of the regression coefficients. At the population level, the negative derivative of the optimal convex loss is the best decreasing approximation of the derivative of the log-density of the noise distribution. This motivates a fitting process via a nonparametric extension of score…

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Semiparametric Bernstein–von Mises phenomenon via Isotonized Posterior in Wicksell’s problem

Wicksell 问题中经保序化后验的半参数 Bernstein–von Mises 现象

In this paper, we propose a novel Bayesian approach for nonparametric estimation in Wicksell’s problem. This has important applications in astronomy for estimating the distribution of the positions of the stars in a galaxy given projected stellar positions and in materials science to determine the 3D microstructure of a material, using its 2D cross-sections. We deviate from the classical Bayesian nonparametric approach, which would place a Dirichlet Process (DP) prior on the…

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Berry–Esseen bounds for design-based causal inference with possibly diverging treatment levels and varying group sizes

处理水平可能增长且组规模不等时设计型因果推断的 Berry–Esseen 界

Neyman (1923/1990) introduced the randomization model, which contains the notation of potential outcomes to define causal effects and a framework for large-sample inference based on the design of the experiment. However, the existing theory for this framework is far from complete, especially when the number of treatment levels diverges and the treatment group sizes vary. We provide a unified discussion of statistical inference under the randomization model with general…

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A computational transition for detecting correlated stochastic block models by low-degree polynomials

低阶多项式检测相关随机块模型的计算转变

Detection of correlation in a pair of random graphs is a fundamental statistical and computational problem that has been extensively studied in recent years. In this work, we consider a pair of correlated (sparse) stochastic block models S(n,λn;k,ϵ;s) that are subsampled from a common parent stochastic block model S(n,λn;k,ϵ) with k=O(1) symmetric communities, average degree λ=O(1), divergence parameter ϵ, and subsampling probability s. For the detection problem of…

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Solving the Poisson equation using coupled Markov chains

This article shows how coupled Markov chains that meet exactly after a random number of iterations can be used to generate unbiased estimators of the solutions of the Poisson equation. Through this connection, we rederive known unbiased estimators of expectations with respect to the stationary distribution of a Markov chain and provide conditions for the finiteness of their moments. We further construct unbiased estimators of the asymptotic variance of Markov chain ergodic…

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Average partial effect estimation using double machine learning

利用双重机器学习估计平均偏效应

Single-parameter summaries of variable effects in regression settings are desirable for ease of interpretation. However, (partially) linear models, for example, which would deliver these, may fit poorly to the data. On the other hand, an interpretable summary of the contribution of a given predictor is provided by the so-called average partial effect—the average slope of the regression function with respect to the predictor of interest. Although one can construct a doubly…

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Poisson empirical Bayes estimation: When does g-modeling beat f-modeling in theory (and in practice)?

泊松经验贝叶斯估计:何时先验建模优于边际建模?

Empirical Bayes (EB) is a popular framework for large-scale inference that aims to find data-driven estimators to compete with the Bayesian oracle that knows the true prior. Two principled approaches to EB estimation have emerged over the years: f-modeling, which constructs an approximate Bayes rule by estimating the marginal distribution of the data, and g-modeling, which estimates the prior from data and then applies the learned Bayes rule. For the Poisson model, the…

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Scalable inference in functional linear regression with streaming data

流式数据下函数线性回归的可扩展推断

Traditional static functional data analysis is facing new challenges due to streaming data, where data constantly flows in. A major challenge is that storing such an ever-increasing amount of data in memory is nearly infeasible. In addition, existing inferential tools in online learning are mainly developed for finite-dimensional problems, while inference methods for functional data are focused on the offline settings. In this paper, we focus on the online estimation of…

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A UNIFIED THEORY FOR ARMA MODELS WITH VARYING COEFFICIENTS: ONE SOLUTION FITS ALL

变系数 ARMA 模型的统一理论与显式解

A new explicit solution representation is provided for ARMA recursions with drift and either deterministically or stochastically varying coefficients. It is expressed in terms of the determinants of banded Hessenberg matrices and, as such, is an explicit function of the coefficients. In addition to computational efficiency, the proposed solution provides a more explicit analysis of the fundamental properties of such processes, including their Wold–Cramér decomposition, their…

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OPTIMAL MODEL AVERAGING FOR JOINT VALUE-AT-RISK AND EXPECTED SHORTFALL REGRESSION

风险价值与期望损失联合回归的最优模型平均

Since the implementation of the Basel III Accord, expected shortfall (ES) has gained increasing attention from regulators as a complement to value-at-risk (VaR). The problem of elicitability for ES makes jointly modeling VaR and ES a popular method to study ES. In this article, we develop model averaging for joint VaR and ES regression models that selects the two weight vectors by minimizing a jackknife criterion. We show the large sample properties of the estimators under…

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A GENERAL LIMIT THEORY FOR NONLINEAR FUNCTIONALS OF NONSTATIONARY TIME SERIES

非平稳时间序列非线性泛函的一般极限理论

New limit theory is provided for a wide class of sample variance and covariance functionals involving both nonstationary and stationary time series. Sample functionals of this type commonly appear in regression applications and the asymptotics are particularly relevant to estimation and inference in nonlinear nonstationary regressions that involve unit root, local unit root, or fractional processes. The limit theory is unusually general in that it covers both parametric and…

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INFERENCE ON EXTREME QUANTILES OF UNOBSERVED INDIVIDUAL HETEROGENEITY

未观测个体异质性极端分位数的推断

We develop a methodology for conducting inference on extreme quantiles of unobserved individual heterogeneity (e.g., heterogeneous coefficients and treatment effects) in panel data and meta-analysis settings. Inference is challenging in such settings: only noisy estimates of heterogeneity are available, and central limit approximations perform poorly in the tails. We derive a necessary and sufficient condition under which noisy estimates are informative about extreme…

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IDENTIFICATION-ROBUST TWO-STAGE BOOTSTRAP TESTS WITH PRETESTING FOR EXOGENEITY

带外生性预检验的识别稳健两阶段bootstrap检验

Pretesting for exogeneity has become routine in many empirical applications involving instrumental variables (IVs) to decide whether the ordinary least squares or IV-based method is appropriate. Guggenberger (2010a, Econometric Theory , 26, 369–382) shows that the second-stage test – based on the outcome of a Durbin-Wu-Hausman-type pretest in the first stage – exhibits extreme size distortion, with asymptotic size equal to 1 when the standard critical values are used. In…

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Robust IV inference with clustering dependence

聚类相依下的稳健工具变量推断

Summary Linear instrumental variables (IV) models with clustering dependence are widely used in empirical studies, although the common solution, the cluster covariance estimator, often produces undesirable inferential results, especially with weak instruments. In this paper, I propose a method that is robust to both weak IV and (potentially heterogeneous) clustering dependence. The proposed method is based on the idea of Fama–MacBeth estimation, with group-level estimators…

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Comparing predictive ability in the presence of instability over a very short time

短暂不稳定情形下的预测能力比较

Summary We consider forecast comparison in the presence of instability when this affects only a short period of time. We demonstrate that global tests do not perform well in this case because they were not designed to capture very short-lived instabilities, and their power vanishes altogether when the magnitude of the shock is very large. We then discuss non-parametric approaches that are more suitable to detect such situations. We illustrate these results in a Monte Carlo…

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Using post-regularization distribution regression to measure the effects of a minimum wage on hourly wages, hours worked, and monthly earnings

利用正则化后分布回归评估最低工资的分布效应

Summary We evaluate the distributional effects of a minimum wage introduction based on a dataset with a moderate sample size, but a large number of potential covariates. In this context, the selection of relevant control variables at each distributional threshold is crucial to test hypotheses about the impact of the continuous treatment variable. To this end, we use a post-double-selection logistic distribution regression approach, which allows for uniformly valid inference…

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