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Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

利用稳健调整剖面得分进行双样本汇总数据孟德尔随机化推断

Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science. In this paper, we study statistical inference in the increasingly popular two-sample summary-data MR design. We show a linear model for the observed associations approximately holds in a wide variety of settings when all the genetic variants…

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Locked in by leverage: Job search during the housing crisis

被杠杆锁定:住房危机期间的求职行为

This paper examines how housing market distress affects job search. Using data from a leading online job search platform during the Great Recession, we find that job seekers in areas with depressed housing markets apply for fewer jobs that require relocation. With their search constrained geographically, job seekers broaden their search for lower-level positions nearby. These effects are stronger for job seekers with recourse mortgages, which we confirm using a spatial…

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Double/debiased machine learning for difference-in-differences models

双重差分模型中的双重/去偏机器学习

Summary This paper provides an orthogonal extension of the semiparametric difference-in-differences estimator proposed in earlier literature. The proposed estimator enjoys the so-called Neyman orthogonality (Chernozhukov et al., 2018), and thus it allows researchers to flexibly use a rich set of machine learning methods in the first-step estimation. It is particularly useful when researchers confront a high-dimensional data set in which the number of potential control…

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Wild bootstrap for fuzzy regression discontinuity designs: obtaining robust bias-corrected confidence intervals

模糊断点回归的野生自助法:构造稳健偏差校正置信区间

Summary This paper develops a novel wild bootstrap procedure to construct robust bias-corrected valid confidence intervals for fuzzy regression discontinuity designs, providing an intuitive complement to existing robust bias-corrected methods. The confidence intervals generated by this procedure are valid under conditions similar to the procedures proposed by Calonico et al. (2014) and related literature. Simulations provide evidence that this new method is at least as…

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Optimal bandwidth choice for robust bias-corrected inference in regression discontinuity designs

断点回归中稳健偏差校正推断的最优带宽选择

Summary Modern empirical work in regression discontinuity (RD) designs often employs local polynomial estimation and inference with a mean square error (MSE) optimal bandwidth choice. This bandwidth yields an MSE-optimal RD treatment effect estimator, but is by construction invalid for inference. Robust bias-corrected (RBC) inference methods are valid when using the MSE-optimal bandwidth, but we show that they yield suboptimal confidence intervals in terms of coverage error.…

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Double machine learning with gradient boosting and its application to the Big N audit quality effect

梯度提升双重机器学习及其对大型审计机构质量效应的应用

In this paper, we study the double machine learning (DML) approach of Chernozhukov et al. (2018) for estimating average treatment effect and apply this approach to examine the Big N audit quality effect in the accounting literature. This approach relies on machine learning methods and is suitable when a high dimensional nuisance function with many covariates is present in the model. This approach does not suffer from the “regularization bias” when a learning method with a…

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Noncausal vector AR processes with application to economic time series

非因果向量自回归过程及其经济时间序列应用

Inference procedures for noncausal autoregressive (AR) models have been well studied and applied in a variety of applications from environmental to financial. For such processes, the observation at time t may depend on both past and future shocks in the system. In this paper, we consider extension of the univariate noncausal AR models to the vector AR (VAR) case. The extension presents several interesting challenges since even a first-order VAR can possess both causal and…

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Nonparametric Instrumental Variable Methods for Dynamic Treatment Evaluation

动态处理效应评估的非参数工具变量方法

We develop an instrumental variable approach for identification of dynamic treatment effects on survival outcomes in the presence of dynamic selection, noncompliance, and right-censoring. The approach is nonparametric and does not require independence of observed and unobserved characteristics or separability assumptions. We propose estimation procedures and derive asymptotic properties. We apply our approach to evaluate a policy reform in which the pathway of unemployment…

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Treatment and Spillover Effects Under Network Interference

网络干扰下的处理效应与溢出效应

We study nonparametric and regression estimators of treatment and spillover effects when interference is mediated by a network. Inference is nonstandard due to dependence induced by treatment spillovers and network-correlated effects. We derive restrictions on the network degree distribution under which the estimators are consistent and asymptotically normal and show they can be verified under a strategic model of network formation. We also construct consistent variance…

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MIMIX: A Bayesian Mixed-Effects Model for Microbiome Data From Designed Experiments

MIMIX:用于设计实验微生物组数据的贝叶斯混合效应模型

Recent advances in bioinformatics have made high-throughput microbiome data widely available, and new statistical tools are required to maximize the information gained from these data. For example, analysis of high-dimensional microbiome data from designed experiments remains an open area in microbiome research. Contemporary analyses work on metrics that summarize collective properties of the microbiome, but such reductions preclude inference on the fine-scale effects of…

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Estimating Dynamic Treatment Regimes in Mobile Health Using V-Learning

用 V-learning 估计移动健康中的动态处理策略

The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best possible health-care for each patient. Mobile technologies have an important role to play in this vision as they offer a means to monitor a patient's health status in real-time and subsequently to deliver interventions if, when, and in the dose that they are needed. Dynamic treatment regimes formalize individualized treatment plans as…

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A Comparison of Two Quantile Models With Endogeneity

两种含内生性的分位数模型比较

This article studies the relationship between the two most-used quantile models with endogeneity: the instrumental variable quantile regression (IVQR) model (Chernozhukov and Hansen 2005) and the local quantile treatment effects (LQTE) model (Abadie, Angrist, and Imbens 2002). The key condition of the IVQR model is the rank similarity assumption, a restriction on the evolution of individual ranks across treatment states, under which population quantile treatment effects…

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A Stochastic Frontier Model with Endogenous Treatment Status and Mediator

处理状态与中介变量均内生的随机前沿模型

Government policies are frequently used to promote productivity. Some policies are designed to enhance production technology, while others are meant to improve production efficiency. An important issue to consider when designing and evaluating policies is whether a mediator is required or effective in achieving the desired final outcome. To better understand and evaluate the policies, we propose a new stochastic frontier model with a treatment status and a mediator, both of…

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Identification and Efficiency Bounds for the Average Match Function Under Conditionally Exogenous Matching

条件外生匹配下平均匹配函数的识别与效率界

Consider two heterogenous populations of agents who, when matched, jointly produce an output, Y. For example, teachers and classrooms of students together produce achievement, parents raise children, whose life outcomes vary in adulthood, assembly plant managers and workers produce a certain number of cars per month, and lieutenants and their platoons vary in unit effectiveness. Let W∈W={w1,…,wJ}$W\in \mathbb {W}=\lbrace w_{1},\ldots,w_{J}\rbrace $ and X∈X={x1,…,xK}$X\in \mathbb {X}=\lbrace x_{1},\ldots,x_{K}\rbrace $…

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A Cautionary Tale of Evaluating Identifying Assumptions: Did Reality TV Really Cause a Decline in Teenage Childbearing?

识别假设检验的警示:真人秀真的降低了青少年生育率吗?

Evaluating policy changes that occur everywhere at the same time is difficult because of the lack of a clear counterfactual. Hoping to address this problem, researchers often proxy for differential exposure using some observed characteristic in the pretreatment period. As a cautionary tale of how difficult identification is in such settings, we re-examine the results of an influential paper by Melissa Kearney and Phillip Levine, who found that the MTV program 16 and Pregnant…

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Multiply Robust Causal Inference with Double-Negative Control Adjustment for Categorical Unmeasured Confounding

分类未观测混杂下双重负控调整的多重稳健因果推断

Summary Unmeasured confounding is a threat to causal inference in observational studies. In recent years, the use of negative controls to mitigate unmeasured confounding has gained increasing recognition and popularity. Negative controls have a long-standing tradition in laboratory sciences and epidemiology to rule out non-causal explanations, although they have been used primarily for bias detection. Recently, Miao and colleagues have described sufficient conditions under…

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Model-assisted inference for treatment effects using regularized calibrated estimation with high-dimensional data

高维数据下正则化校准估计的处理效应模型辅助推断

Consider the problem of estimating average treatment effects when a large number of covariates are used to adjust for possible confounding through outcome regression and propensity score models. We develop new methods and theory to obtain not only doubly robust point estimators for average treatment effects, which remain consistent if either the propensity score model or the outcome regression model is correctly specified, but also model-assisted confidence intervals, which…

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Designs for estimating the treatment effect in networks with interference

存在干扰的网络中处理效应估计的实验设计

In this paper, we introduce new, easily implementable designs for drawing causal inference from randomized experiments on networks with interference. Inspired by the idea of matching in observational studies, we introduce the notion of considering a treatment assignment as a “quasi-coloring” on a graph. Our idea of a perfect quasi-coloring strives to match every treated unit on a given network with a distinct control unit that has identical number of treated and control…

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Mixed causal–noncausal autoregressions with exogenous regressors

含外生回归变量的混合因果—非因果自回归模型

Summary Mixed causal–noncausal autoregressive (MAR) models have been proposed to model time series exhibiting nonlinear dynamics. Possible exogenous regressors are typically substituted into the error term to maintain the MAR structure of the dependent variable. We introduce a representation including these covariates called MARX to study their direct impact. The asymptotic distribution of the MARX parameters is derived for a class of non‐Gaussian densities. For a Student…

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Estimation of average treatment effects using panel data when treatment effect heterogeneity depends on unobserved fixed effects

处理效应异质性依赖未观测固定效应时的面板平均处理效应估计

Summary This paper proposes a new panel data approach to identify and estimate the time‐varying average treatment effect (ATE). The approach allows for treatment effect heterogeneity that depends on unobserved fixed effects. In the presence of this type of heterogeneity, existing panel data approaches identify the ATE for limited subpopulations only. In contrast, the proposed approach identifies and estimates the ATE for the entire population. The approach relies on the…

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Model-free approach to quantifying the proportion of treatment effect explained by a surrogate marker

无模型方法量化替代标志物解释的治疗效应比例

Summary In randomized clinical trials, the primary outcome, $Y$, often requires long-term follow-up and/or is costly to measure. For such settings, it is desirable to use a surrogate marker, $S$, to infer the treatment effect on $Y$, $\Delta$. Identifying such an $S$ and quantifying the proportion of treatment effect on $Y$ explained by the effect on $S$ are thus of great importance. Most existing methods for quantifying the proportion of treatment effect are model based and…

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Regularized calibrated estimation of propensity scores with model misspecification and high-dimensional data

模型误设与高维数据下倾向得分的正则化校准估计

Summary Propensity scores are widely used with inverse probability weighting to estimate treatment effects in observational studies. We study calibrated estimation as an alternative to maximum likelihood estimation for fitting logistic propensity score models. We show that, with possible model misspecification, minimizing the expected calibration loss underlying the calibrated estimators involves reducing both the expected likelihood loss and a measure of relative errors…

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Measurement errors in the binary instrumental variable model

二元工具变量模型中的测量误差

Summary Instrumental variable methods can identify causal effects even when the treatment and outcome are confounded. We study the problem of imperfect measurements of the binary instrumental variable, treatment and outcome. We first consider nondifferential measurement errors, that is, the mismeasured variable does not depend on other variables given its true value. We show that the measurement error of the instrumental variable does not bias the estimate, that the…

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From the Fringe to the Fore: Labor Unions and Employee Compensation

从附加福利到核心报酬:工会与员工薪酬

Conventional wisdom suggests that labor unions raise worker wages, while the newer empirical literature finds only negligible earnings effects. I reconcile this apparent contradiction by arguing that collective bargaining targets fringe benefits. Using U.S. firm-level data from the Bureau of Economic Analysis (BEA) Multinational Enterprise Survey and Compustat, I exploit a regression discontinuity in majority rule union elections to compare changes in employee compensation…

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