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随机试验与真实世界数据的弹性整合：处理效应异质性估计AI 解读

Abstract We propose a test-based elastic integrative analysis of the randomised trial and real-world data to estimate treatment effect heterogeneity with a vector of known effect modifiers. When the real-world data are not subject to bias, our approach combines the trial and real-world data for efficient estimation. Utilising the trial design, we construct a test to decide whether or not to use real-world data. We characterise the asymptotic distribution of the test-based…

复杂纵向研究中的近端因果推断AI 解读

Abstract A standard assumption for causal inference about the joint effects of time-varying treatment is that one has measured sufficient covariates to ensure that within covariate strata, subjects are exchangeable across observed treatment values, also known as ‘sequential randomization assumption (SRA)’. SRA is often criticized as it requires one to accurately measure all confounders. Realistically, measured covariates can rarely capture all confounders with certainty.…

用于最优动态治疗策略估计的贝叶斯似然回归AI 解读

Abstract Clinicians often make sequences of treatment decisions that can be framed as dynamic treatment regimes. In this paper, we propose a Bayesian likelihood-based dynamic treatment regime model that incorporates regression specifications to yield interpretable relationships between covariates and stage-wise outcomes. We define a set of probabilistically-coherent properties for dynamic treatment regime processes and present the theoretical advantages that are…

职业技术教育的影响：来自康涅狄格州技术高中体系的证据AI 解读

Abstract We examine the effect of attending stand-alone technical high schools in Connecticut using regression discontinuity. Male students are 10 percentage points more likely to graduate from high school and have half a semester less time enrolled in college. Male students have 32% higher average quarterly earnings. Earnings effects may in part reflect general skills: male students have higher attendance rates and test scores, industry fixed effects explain less than…

疫苗有效性检测阴性设计研究中的双负对照推断AI 解读

The test-negative design (TND) has become a standard approach to evaluate vaccine effectiveness against the risk of acquiring infectious diseases in real-world settings, such as Influenza, Rotavirus, Dengue fever, and more recently COVID-19. In a TND study, individuals who experience symptoms and seek care are recruited and tested for the infectious disease which defines cases and controls. Despite TND's potential to reduce unobserved differences, in healthcare seeking…

观察性区组设计的Bahadur效率AI 解读

To be convincing, an observational or nonrandomized study of causal effects must demonstrate that its conclusions cannot be readily explained by a small unmeasured bias in the way individuals were assigned to treatment or control. The Bahadur relative efficiency of a sensitivity analysis compares the performance of different test statistics or different research designs when sensitivity to unmeasured bias is appraised: better statistics and better designs exhibit…

亚马孙雨林环境政策的最优定向配置AI 解读

Abstract This article sets out a data-driven approach for targeting environmental policies optimally in order to combat deforestation. We focus on the Amazon, the world’s most extensive rainforest, where Brazil’s federal government issued a “Priority List” of municipalities in 2008—a blacklist to be targeted with more intense environmental monitoring and enforcement. First, we estimate the causal impact of the Priority List on deforestation (along with other relevant…

无效工具变量与 GWAS 汇总数据下的转录组关联研究因果推断AI 解读

Transcriptome-wide association studies (TWAS) have recently emerged as a popular tool to discover (putative) causal genes by integrating an outcome GWAS dataset with another gene expression/transcriptome GWAS (called eQTL) dataset. In our motivating and target application, we'd like to identify causal genes for low-density lipoprotein cholesterol (LDL), which is crucial for developing new treatments for hyperlipidemia and cardiovascular diseases. The statistical principle…

识别他汀使用相关二型糖尿病风险最高的亚组：电子健康记录证据AI 解读

There have been increased concerns that the use of statins, one of the most commonly prescribed drugs for treating coronary artery disease, is potentially associated with the increased risk of new-onset Type II diabetes (T2D). Nevertheless, to date, there is no robust evidence supporting as to whether and what kind of populations are indeed vulnerable for developing T2D after taking statins. In this case study, leveraging the biobank and electronic health record data in the…

个体化决策规则的稳健性AI 解读

With the emergence of precision medicine, estimating optimal individualized decision rules (IDRs) has attracted tremendous attention in many scientific areas. Most existing literature has focused on finding optimal IDRs that can maximize the expected outcome for each individual. Motivated by complex individualized decision making procedures and the popular conditional value at risk (CVaR) measure, we propose a new robust criterion to estimate optimal IDRs in order to control…

干预目标不确定时的网络结构学习AI 解读

Gaussian Directed Acyclic Graphs (DAGs) represent a powerful tool for learning the network of dependencies among variables, a task which is of primary interest in many fields and specifically in biology. Different DAGs may encode equivalent conditional independence structures, implying limited ability, with observational data, to identify causal relations. In many contexts however, measurements are collected under heterogeneous settings where variables are subject to…

强化学习框架下A/B测试的动态因果效应评估AI 解读

A/B testing, or online experiment is a standard business strategy to compare a new product with an old one in pharmaceutical, technological, and traditional industries. Major challenges arise in online experiments of two-sided marketplace platforms (e.g., Uber) where there is only one unit that receives a sequence of treatments over time. In those experiments, the treatment at a given time impacts current outcome as well as future outcomes. The aim of this article is to…

存在未测量混杂时多重处理效应的识别AI 解读

Identification of treatment effects in the presence of unmeasured confounding is a persistent problem in the social, biological, and medical sciences. The problem of unmeasured confounding in settings with multiple treatments is most common in statistical genetics and bioinformatics settings, where researchers have developed many successful statistical strategies without engaging deeply with the causal aspects of the problem. Recently there have been a number of attempts to…

利用工具变量识别因果溢出效应AI 解读

I set up a potential outcomes framework to analyze spillover effects using instrumental variables. I characterize the population compliance types in a setting in which spillovers can occur on both treatment take-up and outcomes, and provide conditions for identification of the marginal distribution of compliance types. I show that intention-to-treat (ITT) parameters aggregate multiple direct and spillover effects for different compliance types, and hence do not have a clear…

面向公平性的最优个体化处理规则学习AI 解读

There has recently been a surge on the methodological development for optimal individualized treatment rule (ITR) estimation. The standard methods in the literature are designed to maximize the potential average performance (assuming larger outcomes are desirable). A notable drawback of the standard approach, due to heterogeneity in treatment response, is that the estimated optimal ITR may be suboptimal or even detrimental to certain disadvantaged subpopulations. Motivated…

处理效应模型的面板数据分位数回归AI 解读

In this study, we develop a novel estimation method for quantile treatment effects (QTE) under rank invariance and rank stationarity assumptions. Ishihara (2020 Ishihara, T. (2020), “Identification and Estimation of Time-Varying Nonseparable Panel Data Models Without Stayers,” Journal of Econometrics, 215, 184–208. DOI: https://doi.org/10.1016/j.jeconom.2019.08.008.[Crossref] , [Google Scholar]) explores identification of the nonseparable panel data model under these…

使用二元工具变量识别多元模型的一个条件AI 解读

This article introduces an empirical condition for the nonparametric point-identification of multivariate instrumental variable models with continuous endogenous variables using binary instruments. Verifying this condition can confirm point-identification in settings in which traditional approaches are not applicable. In particular, it shows that nonlinear instrumental variable models with general heterogeneity can be point-identified with only a binary instrument. This…

高维线性中介模型的统计推断及疫情股票反应应用AI 解读

Mediation analysis draws increasing attention in many research areas such as economics, finance and social sciences. In this paper, we propose new statistical inference procedures for high dimensional mediation models, in which both the outcome model and the mediator model are linear with high dimensional mediators. Traditional procedures for mediation analysis cannot be used to make statistical inference for high dimensional linear mediation models due to…

弱工具变量稳健推断中条件似然比及相关检验的功效AI 解读

Power curves of the Conditional Likelihood Ratio (CLR) and related tests for testing H0:β=β0 in linear models with a single endogenous variable, y=xβ+u, estimated using potentially weak instrumental variables have been presented for two different designs. One design keeps the variance matrix of the structural and first-stage errors, Σ, constant, the other instead keeps the variance matrix of the reduced-form and first-stage errors, Ω, constant. The values of Σ govern the…

马克思走向主流：俄国革命对其学术影响力的作用AI 解读

Karl Marx’s high academic stature outside of economics diverges sharply from his peripheral influence within the discipline, particularly after nineteenth-century developments rendered the labor theory of value obsolete. We hypothesize that the 1917 Russian Revolution is responsible for elevating Marx into the academic mainstream. Using the synthetic control method, we construct a counterfactual for Marx’s citation patterns in Google Ngram data. This allows us to predict how…

低秩模型的统计推断AI 解读

This paper studies inference in linear models with a high-dimensional parameter matrix that can be well approximated by a “spiked low-rank matrix.” A spiked low-rank matrix has rank that grows slowly compared to its dimensions and nonzero singular values that diverge to infinity. We show that this framework covers a broad class of models of latent variables, which can accommodate matrix completion problems, factor models, varying coefficient models and heterogeneous…

协变量自适应随机化下分位数处理效应的回归调整估计AI 解读

Datasets from field experiments with covariate-adaptive randomizations (CARs) usually contain extra covariates in addition to the strata indicators. We propose to incorporate these additional covariates via auxiliary regressions in the estimation and inference of unconditional quantile treatment effects (QTEs) under CARs. We establish the consistency and limit distribution of the regression-adjusted QTE estimator and prove that the use of multiplier bootstrap inference is…

具有战略替代性的多重处理AI 解读

We develop an empirical framework to identify and estimate the effects of treatments on outcomes of interest when the treatments are the result of strategic interaction (e.g., bargaining, oligopolistic entry, peer effects). We consider a model where agents play a discrete game of complete information and strategic substitutability, whose equilibrium actions (i.e., binary treatments) determine a post-game outcome in a nonseparable model with endogeneity. Due to the…

Synthetic Learner：随时间变化的处理效应无模型推断AI 解读

Understanding the effect of a particular treatment or a policy pertains to many areas of interest, ranging from political economics, marketing to healthcare. In this paper, we develop a non-parametric algorithm for detecting the effects of treatment over time in the context of Synthetic Controls. The method builds on counterfactual predictions from many algorithms without necessarily assuming that the algorithms correctly capture the model. We introduce an inferential…