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Debiased regression adjustment in completely randomized experiments with moderately high-dimensional covariates

中高维协变量下完全随机实验的去偏回归调整

Completely randomized experiment is the gold standard for causal inference. When the covariate information for each experimental candidate is available, one typical way is to include them in covariate adjustments for more accurate treatment effect estimation. In this paper, we investigate this problem under the randomization-based framework, i.e., that the covariates and potential outcomes of all experimental candidates are assumed as deterministic quantities and the…

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Robust difference-in-differences analysis when there is a term structure

存在期限结构时的稳健双重差分分析

For variables with a term structure, the standard difference-in-differences (DiD) model is predisposed toward misspecification, even under random assignment, because of heterogeneity over the maturity spectrum and imperfect matching between treated and control units. Estimated treatment effects that are false, biased, or hard to interpret become a concern. Neither unit fixed effects nor standard term-structure controls resolve the problem. Solutions that overcome imperfect…

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Redeploying dirty assets: The impact of environmental

污染资产再配置:环境……的影响(原题截断)

This paper investigates how firms’ pollution incentives are influenced by their ability to divest polluted assets. My empirical setting is a major reform that exempts purchasers from liability for past contamination. Using a difference-in-differences framework, I find that the reform reduces toxic emissions, lowers bankruptcy risk, and increases firm value. Cross-sectional tests show that the decline in emissions is driven by firms with weaker financial health and fewer…

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Heterogeneity and Heteroskedasticity in Endogenous Switching Models: Estimating the Effects of Physician Advice on Calorie Consumption

内生转换模型中的异质性与异方差:医生建议对热量摄入的影响

ABSTRACT We describe two‐step control function estimation procedures for estimating average treatment effects in constant coefficient endogenous switching models with a binary treatment. We allow for additional heterogeneity by allowing for heteroskedasticity in the latent error in the treatment assignment equation. We apply our estimation procedures to evaluate the causal effect of physician advice on calorie consumption using National Health and Nutritional Examination…

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The Peer Effect on Future Wages in the Workplace

工作场所同伴对未来工资的影响

ABSTRACT This paper examines workplace peer effects in two directions, leveraging employer‐employee data for Italy. First, using a novel estimation approach and addressing endogenous worker‐peer sorting, we estimate that a 10% increase in peer quality raises one's wage by 1.8% in the next year. The effect declines to 0.7% after 5 years. Second, in an event study around mobility episodes, we quantify wage changes associated with the entry and leave of high‐quality and…

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Permutation Inference with a Finite Number of Heterogeneous Clusters

有限个异质聚类下的置换推断

Abstract I introduce a simple permutation procedure to test conventional (nonsharp) hypotheses about the effect of a binary treatment in the presence of a finite number of large, heterogeneous clusters when the treatment effect is identified by comparisons across clusters. The procedure asymptotically controls size by applying a level-adjusted permutation test to a suitable statistic. The adjusted permutation test is easy to implement in practice and performs well at…

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Debiased learning of the causal net benefit with censored event time data

删失事件时间数据中因果净获益的去偏学习

Summary Cox regression is the default approach to evaluating the (relative) effect of two treatments on a survival endpoint. This standard framework has nonetheless been criticized for its canonical effect measure, the hazard ratio, having a subtle interpretation, thereby hindering policy-making. This in turn has prompted interest in other effects measures, such as the difference in restricted mean survival time, the net benefit and the win ratio, which have become…

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Identifying and bounding the probability of necessity for causes of effects with ordinal outcomes

有序结果中因果必要性概率的识别与界限

Summary Although the existing causal inference literature focuses on the forward-looking perspective by estimating effects of causes, the backward-looking perspective can provide insights into causes of effects. In backward-looking causal inference, the probability of necessity measures the probability that a certain event is caused by the treatment, given the observed treatment and outcome. Most existing results focus on binary outcomes. Motivated by applications with…

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A general form of covariate adjustment in clinical trials under covariate-adaptive randomization

协变量自适应随机化临床试验中的一般协变量调整

Abstract In randomized clinical trials, adjusting for baseline covariates can improve credibility and efficiency for demonstrating and quantifying treatment effects. This article studies the augmented inverse propensity weighted estimator, which is a general form of covariate adjustment that uses linear, generalized linear and nonparametric or machine learning models for the conditional mean of the response given covariates. Under covariate-adaptive randomization, we…

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Improving efficiency in transporting average treatment effects

提高平均处理效应跨总体迁移的估计效率

Abstract We develop flexible, semiparametric estimators of the average treatment effect transported to a new target population, which offer potential efficiency gains. Transport may be of value when the average treatment effect may differ across populations. We consider the setting where differences in the average treatment effect are due to differences in the distribution of effect modifiers, baseline covariates that modify the treatment effect. First, we propose a…

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Robust evaluation of longitudinal surrogate markers with censored data

删失数据下纵向替代指标的稳健评估

Abstract The development of statistical methods to evaluate surrogate markers is an active area of research. In many clinical settings, the surrogate marker is not simply a single measurement but is instead a longitudinal trajectory of measurements over time, e.g. fasting plasma glucose measured every 6 months for 3 years. In general, available methods developed for the single-surrogate setting cannot accommodate a longitudinal surrogate marker. Furthermore, many of the…

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Causal mediation analysis: selection with asymptotically valid inference

因果中介分析:选择与渐近有效推断

Abstract Researchers are often interested in learning not only the effect of treatments on outcomes, but also the mechanisms that transmit these effects. A mediator is a variable that is affected by treatment and subsequently affects outcome. Existing methods for penalized mediation analyses may lead to ignoring important mediators and either assume that finite-dimensional linear models are sufficient to remove confounding bias, or perform no confounding control at all. In…

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Frequentist inference for semi-mechanistic epidemic models with interventions

含干预的半机制流行病模型:频率学派推断

Abstract The effect of public health interventions on an epidemic are often estimated by adding the intervention to epidemic models. During the Covid-19 epidemic, numerous papers used such methods for making scenario predictions. The majority of these papers use Bayesian methods to estimate the parameters of the model. In this article, we show how to use frequentist methods for estimating these effects which avoids having to specify prior distributions. We also use…

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No Free Lunch? Welfare Analysis of Firms Selling Through Expert Intermediaries

没有免费午餐?经由专家中介销售企业的福利分析

Abstract We study how firms target and influence expert intermediaries. In our context, pharmaceutical manufacturers provide payments to physicians during promotional interactions. We develop an identification strategy based on plausibly exogenous variation in payments driven by differential exposure to spillovers from AMC CoI policies. Using a case study of an important class of cardiovascular drugs, we estimate heterogeneous effects of payments on prescribing, with firms…

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Gender Preferences in Job Vacancies and Workplace Gender Diversity

招聘广告中的性别偏好与工作场所性别多样性

Abstract In Spring 2005, the Ombud for Equal Treatment in Austria launched a campaign notifying employers and newspapers that gender preferences in job ads were illegal. At the time, over 40% of vacancies on the nation’s largest job board stated a gender preference; within a year the rate fell below 5%. We merge job board vacancies and employer records to study how the campaign affected hiring choices and the gender diversity of occupations and workplaces. Using pre-campaign…

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Feedback and Learning: The Causal Effects of Reversals on Judicial Decision-Making

反馈与学习:改判对司法决策的因果影响

Abstract Do judges respond to reversals of their decisions? Using random assignment of cases across two stages of the criminal justice system in Norway and a novel dataset linking trial court decisions to reversals in appeals courts, we provide causal evidence on feedback effects in judicial decision-making. By exploiting differences in the tendencies of randomly assigned appeal panels to reverse trial court decisions, we show that trial court judges who receive a reversal…

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Distributional Off-Policy Evaluation in Reinforcement Learning

强化学习中的分布型离策略评估

In the literature of reinforcement learning (RL), off-policy evaluation is mainly focused on estimating a value of a target policy given the pre-collected data generated by some behavior policy. Motivated by the recent success of distributional RL in many practical applications, we study the distributional off-policy evaluation problem in the batch setting when the reward is multi-variate. We propose an offline Wasserstein-based approach to simultaneously estimate the joint…

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Who Are We Missing? : A Principled Approach to Characterizing the Underrepresented Population

我们遗漏了谁?刻画代表不足人群的原则性方法

Randomized controlled trials (RCTs) serve as the cornerstone for understanding causal effects, yet extending inferences to target populations presents challenges due to effect heterogeneity and underrepresentation. Our paper addresses the critical issue of identifying and characterizing underrepresented subgroups in RCTs, proposing a novel framework for refining target populations to improve generalizability. We introduce an optimization-based approach, Rashomon Set of…

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Estimating Heterogeneous Causal Mediation Effects with Bayesian Decision Tree Ensembles

用贝叶斯决策树集成估计异质性因果中介效应

The causal inference literature has increasingly recognized that targeting treatment effect heterogeneity can lead to improved scientific understanding and policy recommendations. Similarly, studying the causal pathway connecting the treatment to the outcome can be useful. We address these problems in the context of causal mediation analysis . We introduce a varying coefficient model based on Bayesian additive regression trees to estimate and regularize heterogeneous causal…

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Safe Policy Learning through Extrapolation: Application to Pre-trial Risk Assessment

通过外推进行安全政策学习:审前风险评估应用

Algorithmic recommendations and decisions have become ubiquitous in today’s society. Many of these data-driven policies, especially in the realm of public policy, are based on known, deterministic rules to ensure their transparency and interpretability. We examine a particular case of algorithmic pre-trial risk assessments in the US criminal justice system, which provide deterministic classification scores and recommendations to help judges make release decisions. Our goal…

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Fast Signal Region Detection With Application to Whole Genome Association Studies

快速信号区域检测及其全基因组关联研究应用

Research on the localization of the genetic basis associated with diseases or traits has been widely conducted in the last few decades. Scan methods have been developed for region-based analysis in whole-genome association studies, helping us better understand how genetics influences human diseases or traits, especially when the aggregated effects of multiple causal variants are present. In this paper, we propose a fast and effective algorithm coupling with high-dimensional…

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Federated Adaptive Causal Estimation (FACE) of Target Treatment Effects

目标处理效应的联邦自适应因果估计

Federated learning of causal estimands may greatly improve estimation efficiency by leveraging data from multiple study sites, but robustness to heterogeneity and model misspecifications is vital for ensuring validity. We develop a Federated Adaptive Causal Estimation (FACE) framework to incorporate heterogeneous data from multiple sites to provide treatment effect estimation and inference for a flexibly specified target population of interest. FACE accounts for site-level…

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Robust Inference for Federated Meta-Learning

联邦元学习的稳健推断

Synthesizing information from multiple data sources is critical to ensure knowledge generalizability. Integrative analysis of multi-source data is challenging due to the heterogeneity across sources and data-sharing constraints due to privacy concerns. In this paper, we consider a general robust inference framework for federated meta-learning of data from multiple sites, enabling statistical inference for the prevailing model, defined as the one matching the majority of the…

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Sensitivity Analysis for Quantiles of Hidden Biases in Matched Observational Studies

匹配观察研究中隐蔽偏差分位数的敏感性分析

Causal conclusions from observational studies may be sensitive to unmeasured confounding. In such cases, a sensitivity analysis is often conducted, which tries to infer the minimum amount of hidden biases or the minimum strength of unmeasured confounding needed in order to explain away the observed association between treatment and outcome. If the needed bias is large, then the treatment is likely to have significant effects. The Rosenbaum sensitivity analysis is a modern…

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