Debiased inverse-variance weighted estimator in two-sample summary-data Mendelian randomization
两样本汇总数据孟德尔随机化中的去偏逆方差加权估计
Mendelian randomization (MR) has become a popular approach to study the effect of a modifiable exposure on an outcome by using genetic variants as instrumental variables. A challenge in MR is that each genetic variant explains a relatively small proportion of variance in the exposure and there are many such variants, a setting known as many weak instruments. To this end, we provide a theoretical characterization of the statistical properties of two popular estimators in MR:…