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疫苗试验主替代指标评价中缺失协变量下的变点推断AI 解读

Summary We consider the use of threshold-based regression models to evaluate immune response biomarkers as principal surrogate markers of a vaccine’s protective effect. Threshold-based regression models, which allow the relationship between a clinical outcome and a covariate to change dramatically across a threshold value in the covariate, have been studied by various authors under fully observed data. Limited research, however, has examined these models in the presence of…

癌症一级与二级预防效果的分别估计：皮肤自检与黑色素瘤病例对照研究AI 解读

Case-control studies increasingly have been used to evaluate the impact of cancer screening strategies. In this context the intent of the screening test has been to reduce cancer mortality by early detection of cancers, permitting curative therapy in some patients who would die of the disease if diagnosis were delayed until the disease was detected clinically. This phenomenon is known as secondary prevention. In an analysis of a case-control study of skin self-examination…

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竞争风险模型中现患生存数据的发生率估计AI 解读

The problem of interest is the estimation of occurrence probabilities based on prevalent data in competing risks models. In the literature, the development of nonparametric methods has relied heavily on the independent competing risks assumption. The primary purpose of this article is to establish a statistical framework without excluding the possibility of dependence among competing risks. This is done through the use of crude hazard functions. The crude hazard functions…