Posterior Probability of Discovery and Expected Rate of Discovery for Multiple Hypothesis Testing and High Throughput Assays
多重检验与高通量检测中的发现后验概率和预期发现率
Technologies of measuring millions of quantities at once have been rapidly developed and used in biological and biomedical research and other fields in the past decade. Yet a key issue remains unsettled, namely, how to control spurious findings for the ensuing massive number of hypothesis tests. An emerging consensus is to control false discovery rate (FDR), with FDR defined as the expected proportion of true nulls among discoveries, and a discovery the rejection of a null…