论文检索

基因与环境交互作用研究中共享遗传对照的使用AI 解读

With the advent of modern genomic methods to adjust for population stratification, the use of external or publicly available controls has become an attractive option for reducing the cost of large-scale case-control genetic association studies. In this article, we study the estimation of joint effects of genetic and environmental exposures from a case-control study where data on genome-wide markers are available on the cases and a set of external controls while data on…

半参数变换模型中的加权 Breslow 型估计与最大似然估计AI 解读

A semiparametric transformation model comprises a parametric component for covariate effects and a nonparametric component for the baseline hazard/intensity. The Breslow-type estimator has been proposed for estimating the nonparametric component in some inefficient estimation procedures. We show that introducing weights into this estimator leads to nonparametric maximum likelihood estimation, with the weights depending on the martingale residuals. The weighted Breslow-type…