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Data integration with high dimensionality

高维数据整合

Summary We consider situations where the data consist of a number of responses for each individual, which may include a mix of discrete and continuous variables. The data also include a class of predictors, where the same predictor may have different physical measurements across different experiments depending on how the predictor is measured. The goal is to select which predictors affect any of the responses, where the number of such informative predictors tends to infinity…

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Collective Estimation of Multiple Bivariate Density Functions With Application to Angular-Sampling-Based Protein Loop Modeling

多个二元密度函数的联合估计及其在蛋白质环建模中的应用

This article develops a method for simultaneous estimation of density functions for a collection of populations of protein backbone angle pairs using a data-driven, shared basis that is constructed by bivariate spline functions defined on a triangulation of the bivariate domain. The circular nature of angular data is taken into account by imposing appropriate smoothness constraints across boundaries of the triangles. Maximum penalized likelihood is used to fit the model and…

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Composite Likelihood Bayesian Information Criteria for Model Selection in High-Dimensional Data

高维数据模型选择的复合似然贝叶斯信息准则

For high-dimensional data sets with complicated dependency structures, the full likelihood approach often leads to intractable computational complexity. This imposes difficulty on model selection, given that most traditionally used information criteria require evaluation of the full likelihood. We propose a composite likelihood version of the Bayes information criterion (BIC) and establish its consistency property for the selection of the true underlying marginal model. Our…

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A Unified Nonparametric Approach for Unbalanced Factorial Designs

不平衡析因设计的统一非参数方法

Motivated by questions arising from the field of statistical genetics, we consider the problem of testing main, nested, and interaction effects in unbalanced factorial designs. Based on the concept of composite linear rank statistics, a new notion of weighted rank is proposed. Asymptotic normality of weighted linear rank statistics is established under mild conditions, and consistent estimators are developed for the corresponding limiting covariance structure. A unified…

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