A General Statistical Framework for Unifying Interval and Linkage Disequilibrium Mapping
统一区间定位与连锁不平衡定位的一般统计框架
The nonrandom association between different genes, termed linkage disequilibrium (LD), provides a powerful tool for high-resolution mapping of quantitative trait loci (QTL) underlying complex traits. This LD-based mapping approach can be made more efficient when it is coupled with interval mapping characterizing the genetic distance between markers and QTL. This article describes a general statistical framework for simultaneously estimating the linkage and LD that are…