Controlling the FDR in Imperfect Matches to an Incomplete Database
不完整数据库中不完美匹配的错误发现率控制
We consider the problem of controlling the FDR among discoveries from searching an incomplete database. This problem differs from the classical multiple testing setting because there are two different types of false discoveries: those arising from objects that have no match in the database and those that are incorrectly matched. We show that commonly used FDR controlling procedures are inadequate for this setup, a special case of which is tandem mass spectrum identification.…