Large Sample Properties of Two Tests for Independent Joint Action of Two Drugs
两种药物独立联合作用检验的大样本性质
Biological models for the independent action of two drugs imply that if the drugs are administered in various combinations of doses, then the corresponding probabilities of response must satisfy certain inequalities if the drugs are acting independently. The hypothesis that the probabilities do satisfy these inequalities can be tested using the likelihood ratio test or using the bootstrap test proposed by Wahrendorf and Brown in 1980. In the simplest dose design, only one…