论文检索

局部协调闭合检验程序的计算捷径AI 解读

The closed testing principle provides a general and simple framework to construct powerful multiple test procedures for k elementary null hypotheses while controlling the familywise error rate in the strong sense. However, the closed testing principle has the disadvantage of leading to the evaluation of O(2k) intersection hypotheses. Multiple test procedures based on the closed testing principle may thus require substantial computational efforts. Consonant closed test…

递归组合检验AI 解读

We present a method that extends the flexibility of adaptive designs to the number of interim analyses and to the choice of decision boundaries. At each stage of the trial, the design of the next stage can be determined using all of the information gathered so far. Additionally, one can specify the next stage as the final stage or can plan a further interim analysis. The method is based on a recursive application of the two-stage combination tests for p values. The crucial…