Robust Microbial Signature Discovery via Post-Selection Inference for Microbiome Compositions
通过选择后推断稳健发现微生物组成特征
Identifying taxa associated with host phenotypes is crucial for understanding host-microbe interactions and their underlying molecular mechanisms. However, analyzing microbiome data presents unique challenges, as the observed abundances of taxa are high-dimensional, compositional, and subject to both sample-specific and taxon-specific biases. Many existing methods for differential abundance testing struggle to balance false discovery rate control with statistical power. In…