Optimal Design for Goodness-of-Fit of the Michaelis–Menten Enzyme Kinetic Function
Michaelis–Menten 酶动力学函数拟合优度的最优设计
We construct efficient designs for the Michaelis–Menten enzyme kinetic model capable of checking model assumptions. An extended model called EMAX is also considered for this purpose. This model is widely used in pharmacokinetics and reduces to the Michaelis–Menten model for a specific choice of parameter settings. Our strategy is to find efficient designs for estimating the parameters in the EMAX model and at the same time test the validity of the Michaelis–Menten model…