论文检索

通过知识驱动的在线多模态自动表型系统降低电子健康记录研究门槛AI 解读

Electronic health records (EHRs) hold great promise for translational research but remain difficult to use at scale because diagnostic codes are noisy, disease-relevant features are hard to identify, high-quality labels are limited and patient-level data sharing is often restricted. We introduce Knowledge-driven Online Multimodal Automated Phenotyping (KOMAP), a unified system for automated, privacy-preserving EHR phenotyping using summary statistics. The system is organized…

结合源分布混合的引导式对抗鲁棒迁移学习AI 解读

Transfer learning is a critical technique that enables the application of knowledge gained from existing tasks or domains to improve performance on a new one, reducing the need for extensive data and training in each new context. Many existing transfer learning methods rely on leveraging information from source populations closely resembling the target population. However, this approach often overlooks valuable knowledge that may be present in different yet potentially…

电子健康记录多模态分析中的对比学习AI 解读

Electronic health record (EHR) systems capture a wealth of multimodal clinical data, encompassing both structured clinical codes and unstructured clinical notes. Yet, many EHR-focused studies have traditionally examined these modalities in isolation or combined them using simplistic methods, overlooking the intrinsic synergy between them. In reality, these modalities are deeply interconnected, each containing clinically relevant and complementary information that, when…

电子健康记录依赖知识图谱的统计推断AI 解读

Abstract The effective analysis of high-dimensional Electronic Health Record (EHR) data, with substantial potential for healthcare research, presents notable methodological challenges. Employing predictive modeling guided by a knowledge graph (KG), which enables efficient feature selection, can enhance both statistical efficiency and interpretability. While various methods have emerged for constructing KGs, existing techniques often lack statistical certainty concerning the…

目标处理效应的联邦自适应因果估计AI 解读

Federated learning of causal estimands may greatly improve estimation efficiency by leveraging data from multiple study sites, but robustness to heterogeneity and model misspecifications is vital for ensuring validity. We develop a Federated Adaptive Causal Estimation (FACE) framework to incorporate heterogeneous data from multiple sites to provide treatment effect estimation and inference for a flexibly specified target population of interest. FACE accounts for site-level…

联邦元学习的稳健推断AI 解读

Synthesizing information from multiple data sources is critical to ensure knowledge generalizability. Integrative analysis of multi-source data is challenging due to the heterogeneity across sources and data-sharing constraints due to privacy concerns. In this paper, we consider a general robust inference framework for federated meta-learning of data from multiple sites, enabling statistical inference for the prevailing model, defined as the one matching the majority of the…

半监督三重稳健归纳迁移学习AI 解读

In this work, we propose a Semi-supervised Triply Robust Inductive transFer LEarning (STRIFLE) approach, which integrates heterogeneous data from a label-rich source population and a label-scarce target population and uses a large amount of unlabeled data simultaneously to improve the learning accuracy in the target population. Specifically, we consider a high dimensional covariate shift setting and employ two nuisance models, a density ratio model and an imputation model,…

高维特征下的双重稳健增广模型准确度迁移推断AI 解读

Transfer learning is crucial for training models that generalize to unlabeled target populations using labeled source data, especially in real-world studies where label scarcity and covariate shift are common. While most research focuses on model estimation, there is limited literature on transfer inference for model accuracy despite its importance. We introduce a novel Doubly Robust Augmented Model Accuracy Transfer Inferen Ce (DRAMATIC) method for point and interval…

利用光滑 Fisher 一致替代损失寻找最优动态治疗方案AI 解读

Large health care data repositories such as electronic health records (EHR) open new opportunities to derive individualized treatment strategies for complicated diseases such as sepsis. In this paper, we consider the problem of estimating sequential treatment rules tailored to a patient’s individual characteristics, often referred to as dynamic treatment regimes (DTRs). Our main objective is to find the optimal DTR that maximizes a discontinuous value function through direct…

识别他汀使用相关二型糖尿病风险最高的亚组：电子健康记录证据AI 解读

There have been increased concerns that the use of statins, one of the most commonly prescribed drugs for treating coronary artery disease, is potentially associated with the increased risk of new-onset Type II diabetes (T2D). Nevertheless, to date, there is no robust evidence supporting as to whether and what kind of populations are indeed vulnerable for developing T2D after taking statins. In this case study, leveraging the biobank and electronic health record data in the…

保护个体数据的高维异质研究整合回归AI 解读

Evidence-based decision making often relies on meta-analyzing multiple studies, which enables more precise estimation and investigation of generalizability. Integrative analysis of multiple heterogeneous studies is, however, highly challenging in the ultra high-dimensional setting. The challenge is even more pronounced when the individual-level data cannot be shared across studies, known as DataSHIELD contraint. Under sparse regression models that are assumed to be similar…

分层抽样下半监督预测规则的高效评估AI 解读

Abstract In many contemporary applications, large amounts of unlabelled data are readily available while labelled examples are limited. There has been substantial interest in semi-supervised learning (SSL) which aims to leverage unlabelled data to improve estimation or prediction. However, current SSL literature focuses primarily on settings where labelled data are selected uniformly at random from the population of interest. Stratified sampling, while posing additional…

配对错配污染下的球面回归及自动知识转换应用AI 解读

Motivated by a series of applications in data integration, language translation, bioinformatics, and computer vision, we consider spherical regression with two sets of unit-length vectors when the data are corrupted by a small fraction of mismatch in the response-predictor pairs. We propose a three-step algorithm in which we initialize the parameters by solving an orthogonal Procrustes problem to estimate a translation matrix W ignoring the mismatch. We then estimate a…

高维模型中个体化处理效应的最优统计推断AI 解读

Abstract The ability to predict individualized treatment effects (ITEs) based on a given patient's profile is essential for personalized medicine. We propose a hypothesis testing approach to choosing between two potential treatments for a given individual in the framework of high-dimensional linear models. The methodological novelty lies in the construction of a debiased estimator of the ITE and establishment of its asymptotic normality uniformly for an arbitrary future…

无模型方法量化替代标志物解释的治疗效应比例AI 解读

Summary In randomized clinical trials, the primary outcome, $Y$, often requires long-term follow-up and/or is costly to measure. For such settings, it is desirable to use a surrogate marker, $S$, to infer the treatment effect on $Y$, $\Delta$. Identifying such an $S$ and quantifying the proportion of treatment effect on $Y$ explained by the effect on $S$ are thus of great importance. Most existing methods for quantifying the proportion of treatment effect are model based and…

半监督环境下高效且自适应的线性回归AI 解读

We consider the linear regression problem under semi-supervised settings wherein the available data typically consists of: (i) a small or moderate sized “labeled” data, and (ii) a much larger sized “unlabeled” data. Such data arises naturally from settings where the outcome, unlike the covariates, is expensive to obtain, a frequent scenario in modern studies involving large databases like electronic medical records (EMR). Supervised estimators like the ordinary least squares…

高效评估模型预测表现的半监督方法AI 解读

Summary In many modern machine learning applications, the outcome is expensive or time consuming to collect whereas the predictor information is easy to obtain. Semi-supervised (SS) learning aims at utilizing large amounts of ‘unlabelled’ data along with small amounts of ‘labelled’ data to improve the efficiency of a classical supervised approach. Though numerous SS learning classification and prediction procedures have been proposed in recent years, no methods currently…

两阶段抽样下生存结局时变准确性指标的非参数极大似然估计AI 解读

Large prospective cohort studies of rare chronic diseases require thoughtful planning of study designs, especially for biomarker studies when measurements are based on stored tissue or blood specimens. Two-phase designs, including nested case–control and case-cohort sampling designs, provide cost-effective strategies for conducting biomarker evaluation studies.Existing literature for biomarker assessment under two-phase designs largely focuses on simple inverse probability…

利用基线信息进行结局预测的最优分层AI 解读

A common practice in predictive medicine is to use current study data to construct a stratification procedure, which groups subjects according to baseline information and forms stratum-specific prevention or intervention strategies. A desirable stratification scheme would not only have small intra-stratum variation but also have a clinically meaningful discriminatory capability. We show how to obtain optimal stratification rules with such desirable properties from fitting a…

结构化矩阵补全及其基因组数据整合应用AI 解读

Matrix completion has attracted significant recent attention in many fields including statistics, applied mathematics and electrical engineering. Current literature on matrix completion focuses primarily on independent sampling models under which the individual observed entries are sampled independently. Motivated by applications in genomic data integration, we propose a new framework of structured matrix completion (SMC) to treat structured missingness by design.…

差异网络检验及其在基因交互识别中的应用AI 解读

Model organisms and human studies have yielded increasing empirical evidence that interactions among genes contribute broadly to genetic variation of complex traits. In the presence of gene-gene interactions, the dimensionality of the feature space becomes extremely high relative to the sample size. This poses a significant methodological challenge in the identification of gene-gene interactions. In this paper, by using a Gaussian graphical model framework, we translate the…

基于自适应朴素贝叶斯核机器模型的疾病风险分类AI 解读

Genetic studies of complex traits have uncovered only a small number of risk markers explaining a small fraction of heritability and adding little improvement to disease risk prediction. Standard single marker methods may lack power in selecting informative markers or estimating effects. Most existing methods also typically do not account for non-linearity. Identifying markers with weak signals and estimating their joint effects among many non-informative markers remains…

随机临床试验中生存率与治疗效应的界标估计AI 解读

In many studies with a survival outcome, it is often not feasible to fully observe the primary event of interest. This often leads to heavy censoring and thus, difficulty in efficiently estimating survival or comparing survival rates between two groups. In certain diseases, baseline covariates and the event time of nonfatal intermediate events may be associated with overall survival. In these settings, incorporating such additional information may lead to gains in efficiency…

嵌套病例对照研究中的推断重抽样程序AI 解读

The nested case-control (NCC) design have been widely adopted as a cost-effective solution in many large cohort studies for risk assessment with expensive markers, such as the emerging biologic and genetic markers. To analyze data from NCC studies, conditional logistic regression (Goldstein and Langholz, 1992; Borgan et al., 1995) and maximum likelihood (Scheike and Juul, 2004; Zeng et al., 2006) based methods have been proposed. However, most of these methods either cannot…