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通过选择后推断稳健发现微生物组成特征AI 解读

Identifying taxa associated with host phenotypes is crucial for understanding host-microbe interactions and their underlying molecular mechanisms. However, analyzing microbiome data presents unique challenges, as the observed abundances of taxa are high-dimensional, compositional, and subject to both sample-specific and taxon-specific biases. Many existing methods for differential abundance testing struggle to balance false discovery rate control with statistical power. In…

泊松因子模型的数据稀释及其应用AI 解读

The Poisson factor model is a powerful tool for dimension reduction and visualization of large-scale count datasets across diverse domains. Despite the availability of efficient algorithms for estimating factors and loadings, existing methods either require prior knowledge of the number of factors, or resort to ad hoc criteria for its determination. This article proposes a novel data-driven criterion called Information Criterion via Data Thinning (ICDT), leveraging the…

用于提取微生物组成的零膨胀逻辑正态多项模型AI 解读

High throughput sequencing data collected to study the microbiome provide information in the form of relative abundances and should be treated as compositions. Although many approaches including scaling and rarefaction have been proposed for converting raw count data into microbial compositions, most of these methods simply return zero values for zero counts. However, zeros can distort downstream analyses, and they can also pose problems for composition-aware methods. This…

Tao Wang 对《Varimax 旋转的经典因子分析可进行统计推断》的讨论AI 解读

I congratulate the authors on their excellent paper studying the fundamental mechanism of PCA with the Varimax rotation. The paper thoughtfully establishes theorems to demonstrate that the Varimax rotation can supply an unified estimating technique for a wide range of semiparametric factor models. My discussion will be primarily centred on clarification and potential extensions. The paper illustrates that if PCA is performed on a matrix with independent elements, PCA with…

因子增强逆回归及其微生物组数据分析应用AI 解读

We investigate the relationship between count data that inform the relative abundance of features of a composition, and factors that influence the composition. Our work is motivated from microbiome studies aiming to extract microbial signatures that are predictive of host phenotypes based on data collected from a group of individuals harboring radically different microbial communities. We introduce multinomial Factor Augmented Inverse Regression (FAIR) of the count vector…

半参数部分线性变系数众数回归AI 解读

We in this paper propose a semiparametric partially linear varying coefficient (SPLVC) modal regression, in which the conditional mode function of the response variable given covariates admits a partially linear varying coefficient structure. In comparison to existing regressions, the newly developed SPLVC modal regression captures the “most likely” effect and provides superior prediction performance when the data distribution is skewed. The consistency and asymptotic…

SUMMARY We propose counting process-based dimension reduction methods for right-censored survival data. Semiparametric estimating equations are constructed to estimate the dimension reduction subspace for the failure time model. Our methods address two limitations of existing approaches. First, using the counting process formulation, they do not require estimation of the censoring distribution to compensate for the bias in estimating the dimension reduction subspace. Second,…

参数单指标模型检验：降维模型自适应方法AI 解读

Summary Local smoothing testing based on multivariate non-parametric regression estimation is one of the main model checking methodologies in the literature. However, the relevant tests suffer from the typical curse of dimensionality, resulting in slow rates of convergence to their limits under the null hypothesis and less deviation from the null hypothesis under alternative hypotheses. This problem prevents tests from maintaining the level of significance well and makes…

多期企业违约预测：前瞻强度方法AI 解读

A forward intensity model for the prediction of corporate defaults over different future periods is proposed. Maximum pseudo-likelihood analysis is then conducted on a large sample of the US industrial and financial firms spanning the period 1991–2011 on a monthly basis. Several commonly used factors and firm-specific attributes are shown to be useful for prediction at both short and long horizons. Our implementation also factors in momentum in some variables and documents…