Optimal Allocation of Gold Standard Testing Under Constrained Availability: Application to Assessment of HIV Treatment Failure
供应受限时金标准检测的最优分配：HIV治疗失败评估应用
The World Health Organization (WHO) guidelines for monitoring the effectiveness of HIV treatment in resource-limited settings (RLS) are mostly based on clinical and immunological markers (e.g., CD4 cell counts). Recent research indicates that the guidelines are inadequate and can result in high error rates. Viral load (VL) is considered the "gold standard", yet its widespread use is limited by cost and infrastructure. In this paper, we propose a diagnostic algorithm that…