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利用纵向健康信息学数据对复发事件进行全局与发作特异性预测AI 解读

Accurate prediction of recurrent clinical events is crucial for effective management of chronic conditions such as cancer and cardiovascular disease. In recent years, longitudinal health informatics databases, which routinely collect data on repeated clinical events, have been increasingly utilized to construct risk prediction models. We introduce a novel nonparametric framework to predict recurrent events on a gap time scale using survival tree ensembles. Our framework…

计数过程形状与规模指标的统计推断AI 解读

Summary Single-index models have gained increased popularity in time-to-event analysis owing to their model flexibility and advantage in dimension reduction. We propose a semiparametric framework for the rate function of a recurrent event counting process by modelling its size and shape components with single-index models. With additional monotone constraints on the two link functions for the size and shape components, the proposed model possesses the desired directional…

复发事件与失效时间的联合尺度变换模型AI 解读

Recurrent event data arise frequently in various fields such as biomedical sciences, public health, engineering, and social sciences. In many instances, the observation of the recurrent event process can be stopped by the occurrence of a correlated failure event, such as treatment failure and death. In this article, we propose a joint scale-change model for the recurrent event process and the failure time, where a shared frailty variable is used to model the association…

分层抽样下聚类失效时间的半参数加速失效时间建模AI 解读

Clustered failure times often arise from studies with stratified sampling designs where it is desired to reduce both cost and sampling error. Semiparametric accelerated failure time (AFT) models have not been used as frequently as Cox relative risk models in such settings due to lack of efficient and reliable computing routines for inferences. The challenge roots in the nonsmoothness of the rank-based estimating functions, and for clustered data, the asymptotic properties of…