Multiple regression approach to mapping of quantitative trait loci (QTL) based on sib-pair data: a theoretical analysis
基于同胞配对数据定位数量性状位点的多元回归理论分析
The interval mapping method has been shown to be a powerful tool for mapping QTL. However, it is still a challenge to perform a simultaneous analysis of several linked QTLs, and to isolate multiple linked QTLs. To circumvent these problems, multiple regression analysis has been suggested for experimental species. In this paper, the multiple regression approach is extended to human sib-pair data through multiple regression of the squared difference in trait values between two…