Optimal Designs for Dose–Response Models With Restricted Design Spaces
受限设计空间下剂量反应模型的最优设计
In dose–response studies, the dose range is often restricted because of concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose–response curve for a restricted or unrestricted dose range with respect to a broad class of optimality criteria. The underlying curve belongs to a diversified set of link functions suitable for the dose–response studies and having a common canonical form. These include the fundamental binary response…