A Bayesian Approach for Incorporating Variable Rates of Heterogeneity in Linkage Analysis
在遗传连锁分析中纳入不同异质性水平的贝叶斯方法
A widely used approach for dealing with locus heterogeneity in linkage analysis is based on mixture likelihood, in which a single mixing (heterogeneity) parameter represents the probability that each family is of linked type. However, in general, different types of families exhibit different heterogeneity levels. To incorporate this variability, we propose a new approach wherein each family has its own heterogeneity parameter representing the probability that it is of linked…