Maximum likelihood for high-noise group orbit estimation and single-particle cryo-EM
高噪声群轨道估计与单颗粒冷冻电镜中的最大似然
Motivated by applications to single-particle cryo-electron microscopy (cryo-EM), we study several problems of function estimation in a high noise regime, where samples are observed after random rotation and possible linear projection of the function domain. We describe a stratification of the Fisher information eigenvalues according to transcendence degrees of graded pieces of the algebra of group invariants, and we relate critical points of the log-likelihood landscape to a…