Modified Large-Sample Confidence Intervals for Linear Combinations of Variance Components
方差分量线性组合的修正大样本置信区间
We consider the problem of setting a confidence interval or bound for a linear combination of variance components related to a multivariate normal distribution, which includes important applications such as comparing variance components and testing the bioequivalence between two drug products. The lack of an exact confidence interval for a general linear combination of variance components spurred the development of a modified large-sample (MLS) method that was shown to be…