A Flexible Zero-Inflated Poisson-Gamma Model with Application to Microbiome Sequence Count Data
灵活的零膨胀泊松–伽马模型及微生物组序列计数应用
In microbiome studies, it is of interest to use a sample from a population of microbes, such as the gut microbiota community, to estimate the population proportion of these taxa. However, due to biases introduced in sampling and preprocessing steps, these observed taxa abundances may not reflect true taxa abundance patterns in the ecosystem. Repeated measures, including longitudinal study designs, may be potential solutions to mitigate the discrepancy between observed…