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可能误设的边际结构 Cox 模型下的双重稳健估计AI 解读

Summary In this article we consider the marginal structural Cox model, which has been widely used to analyse observational studies with survival outcomes. The standard inverse probability weighting method under the model hinges on a propensity score model for the treatment assignment and a censoring model that incorporates both the treatment and the covariates. In such settings model misspecification can often occur, and the Cox regression model’s non-collapsibility has…

协变量诱导的依赖左截断下的双重稳健估计AI 解读

Summary In prevalent cohort studies with follow-up, the time-to-event outcome is subject to left truncation leading to selection bias. For estimation of the distribution of the time to event, conventional methods adjusting for left truncation tend to rely on the quasi-independence assumption that the truncation time and the event time are independent on the observed region. This assumption is violated when there is dependence between the truncation time and the event time,…

高维混杂下加性风险模型的治疗效应估计AI 解读

Estimating treatment effects for survival outcomes in the high-dimensional setting is critical for many biomedical applications and any application with censored observations. This article establishes an “orthogonal” score for learning treatment effects, using observational data with a potentially large number of confounders. The estimator allows for root-n, asymptotically valid confidence intervals, despite the bias induced by the regularization. Moreover, we develop a…

条件生存函数的比例风险估计AI 解读

Summary We introduce a new estimator of the conditional survival function given some subset of the covariate values under a proportional hazards regression. The new estimate does not require estimating the base-line cumulative hazard function. An estimate of the variance is given and is easy to compute, involving only those quantities that are routinely calculated in a Cox model analysis. The asymptotic normality of the new estimate is shown by using a central limit theorem…