Small Sample LD 50 Confidence Intervals Using Saddlepoint Approximations
利用鞍点近似构造小样本半数致死剂量置信区间
Confidence intervals for the median lethal dose (LD50) and other dose percentiles in logistic regression models are developed using a generalization of the Fieller theorem for exponential families and saddlepoint approximations. Simulation results show that, in terms of one-tailed and two-tailed coverage, the proposed methodology generally outperforms competing confidence intervals obtained from the classical Fieller, likelihood ratio, and score methods. In terms of…