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由纵向分类数据估计事件发生时间AI 解读

The expanded disability status scale (EDSS) is an ordinal score that measures progression in multiple sclerosis (MS). Progression is defined as reaching EDSS of a certain level (absolute progression) or increasing of one point of EDSS (relative progression). Survival methods for time to progression are not adequate for such data since they do not exploit the EDSS level at the end of follow-up. Instead, we suggest a Markov transitional model applicable for repeated…

基于条件 Kendall τ 的失效时间与截断时间拟独立性检验AI 解读

Truncated survival data arise when the failure time is observed only if it falls within a subject-specific truncating set. Most analysis methods rely on the key assumption of quasi-independence, that is, factorization of the joint density of failure and truncation times into a product proportional to the individual densities in the observable region. Unlike independence of failure time and censoring time, quasi-independence can be tested. Tests of quasi-independence are…

中间事件受删失时生存数据的局部似然分析AI 解读

AIDS Clinical Trials Group protocol 193A was a randomized trial designed to compare survival and progression-free survival among patients on different treatment regimens. A complicating feature of the analysis of progression-free survival is that different censoring mechanisms operated on progression and survival, which resulted in more complete information on survival. A simple analysis that uses the minimum of the times to progression and survival and the minimum of the…