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可交换二元数据的独立性、处理异质性与剂量趋势检验AI 解读

Existing methods of testing for treatment effects for clustered binary data include the beta-binomial, quasilikelihood GEE procedures. All of these methods revolve around the mean response and the second-order correlation. However, these two parameters alone do not fully determine the effect of treatment. This article develops nonparametric likelihood ratio procedures to test for independence, heterogeneity dose-related trend in dose—response studies involving exchangeable…

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致畸效应的定量风险评估AI 解读

This article presents a quantitative procedure for using a “benchmark dose” to obtain low-dose risk estimates for reproductive and developmental toxic effects. This procedure combines the best features of the previously proposed methods for handling litter effects for teratology data and the currently used methods for quantitative risk assessment. The beta-binomial distribution is used to account for litter effects, and the Weibull dose—response model is used for modeling…