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A Model-Based Background Adjustment for Oligonucleotide Expression Arrays

寡核苷酸表达芯片的模型化背景校正

High-density oligonucleotide expression arrays are widely used in many areas of biomedical research. Affymetrix GeneChip arrays are the most popular. In the Affymetrix system, a fair amount of further preprocessing and data reduction occurs after the image-processing step. Statistical procedures developed by academic groups have been successful in improving the default algorithms provided by the Affymetrix system. In this article we present a solution to one of the…

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Local Harmonic Estimation in Musical Sound Signals

音乐声音信号的局部谐波估计

Statistical modeling and analysis have been applied to different music-related fields, including sound synthesis and analysis. Sound can be represented as a real-valued function of time. This function can be sampled at a sufficiently small rate such that the resulting discrete version is a good approximation of the continuous version, thus enabling the study of musical sounds as a discrete time series, an entity for which many statistical techniques are available. Physical…

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Information and Posterior Probability Criteria for Model Selection in Local Likelihood Estimation

局部似然估计中模型选择的信息与后验概率准则

Local likelihood estimation has proven to be an effective method for obtaining estimates of parameters that vary with a covariate. To obtain useful estimates of such parameters, approximating models are used. In such cases it is useful to consider window based estimates. We may need to choose between competing approximating models. In this article, we propose a modification to the methods used to motivate many information and posterior probability criteria for the weighted…

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