Inference for covariates that accounts for ascertainment and random genetic effects in family studies
家系研究中兼顾病例入选机制与随机遗传效应的协变量推断
Family studies to identify disease‐related genes often collect families with multiple cases. If environmental exposures or other measured covariates are also important, they should be incorporated into these genetic analyses to control for confounding and increase statistical power. We propose a two‐level mixed effects model that allows us to estimate environmental effects while accounting for varying genetic correlations among family members and adjusting for ascertainment…