Use of the EM algorithm for maximum likelihood estimation in electron microscope autoradiography
电子显微镜放射自显影中基于 EM 的最大似然估计
In this paper we describe a new method for the analysis of electron microscope auto-radiographs. It uses a Poisson model to describe the autoradiographic grain distribution, and the method of maximum likelihood to estimate the radioactive intensities. An iterative procedure is derived from the EM algorithm to produce maximum likelihood estimates. The procedure leads to simple iterative calculations and a complete treatment of edge effects. The resulting method of analysis…