Testing for Gene–Environment and Gene–Gene Interactions Under Monotonicity Constraints
单调性约束下的基因—环境与基因—基因交互检验
Recent genome-wide association studies (GWASs) designed to detect the main effects of genetic markers have had considerable success with many findings validated by replication studies. However, relatively few findings of gene–gene or gene–environment interactions have been successfully reproduced. Besides the main issues associated with insufficient sample size in current studies, a complication is that interactions that rank high based on p-values often correspond to…