Wavelet-Based Nonparametric Modeling of Hierarchical Functions in Colon Carcinogenesis
结肠癌发生中层级函数数据的小波非参数建模
In this article we develop new methods for analyzing the data from an experiment using rodent models to investigate the effect of type of dietary fat on O6-methylguanine-DNA-methyltransferase (MGMT), an important biomarker in early colon carcinogenesis. The data consist of observed profiles over a spatial variable contained within a two-stage hierarchy, a structure that we dub hierarchical functional data. We present a new method providing a unified framework for modeling…