Discussion of “Equi-energy sampler” by Kou, Zhou and Wong
对 Kou、Zhou 与 Wong《等能量采样器》的讨论
Novel sampling algorithms can significantly impact open questions in computational biology, most notably the in silico protein folding problem. By using computational methods, protein folding aims to find the three-dimensional structure of a protein chain given the sequence of its amino acid building blocks. The complexity of the problem strongly depends on the protein representation and its energy function. The more detailed the model, the more complex its corresponding…