An Information Theoretic Approach for Selecting Arms in Clinical Trials
临床试验治疗组选择的信息论方法
Summary The question of selecting the ‘best’ among different choices is a common problem in statistics. In drug development, our motivating setting, the question becomes, for example, which treatment gives the best response rate. Motivated by recent developments in the theory of context-dependent information measures, we propose a flexible response-adaptive experimental design based on a novel criterion governing treatment arm selections which can be used in adaptive…