Latent Variable Poisson Models for Assessing the Regularity of Circadian Patterns over Time
评估昼夜节律随时间规律性的潜变量泊松模型
Many researchers in biology and medicine have focused on trying to understand biological rhythms and their potential impact on disease. A common biological rhythm is circadian, where the cycle repeats itself every 24 hours. However, a disturbance of the circadian pattern may be indicative of future disease. In this article, we develop new statistical methodology for assessing the degree of disturbance or irregularity in a circadian pattern for count sequences that are…