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断点回归设计中由噪声诱导的随机化AI 解读

Summary Regression discontinuity designs assess causal effects in settings where treatment is determined by whether an observed running variable crosses a prespecified threshold. Here, we propose a new approach to identification, estimation and inference in regression discontinuity designs that uses knowledge about exogenous noise (e.g., measurement error) in the running variable. In our strategy, we weight treated and control units to balance a latent variable, of which the…

经验部分贝叶斯多重检验与复合卡方决策AI 解读

A common task in high-throughput biology is to screen for associations across thousands of units of interest, for example, genes or proteins. Often, the data for each unit are modeled as Gaussian measurements with unknown mean and variance and are summarized as per-unit sample averages and sample variances. The downstream goal is multiple testing for the means. In this domain, it is routine to “moderate” (i.e., to shrink) the sample variances through parametric empirical…

通过数据裂分进行经验贝叶斯估计AI 解读

We congratulate Leiner, Duan, Wasserman, and Ramdas on a stimulating article that joins an elegant method to a compelling application. Their article focuses primarily on applications to selective i...

利用重复数据的次序统计量回归进行非参数误差下的经验贝叶斯均值估计AI 解读

We study empirical Bayes estimation of the effect sizes of $N$ units from $K$ noisy observations on each unit. We show that it is possible to achieve near-Bayes optimal mean squared error, without any assumptions or knowledge about the effect size distribution or the noise. The noise distribution can be heteroskedastic and vary arbitrarily from unit to unit. Our proposal, which we call Aurora, leverages the replication inherent in the $K$ observations per unit and recasts…

作者回复：非参数经验贝叶斯分析的置信区间AI 解读

In our article, we introduced two general methods for conducting inference for empirical Bayes estimands. The discussants have contributed to our work by clarifying and raising important issues reg...

非参数经验贝叶斯分析的置信区间AI 解读

In an empirical Bayes analysis, we use data from repeated sampling to imitate inferences made by an oracle Bayesian with extensive knowledge of the data-generating distribution. Existing results provide a comprehensive characterization of when and why empirical Bayes point estimates accurately recover oracle Bayes behavior. In this paper, we develop flexible and practical confidence intervals that provide asymptotic frequentist coverage of empirical Bayes estimands, such as…

利用协变量信息的交叉加权多重检验AI 解读

Abstract A fundamental task in the analysis of data sets with many variables is screening for associations. This can be cast as a multiple testing task, where the objective is achieving high detection power while controlling type I error. We consider m hypothesis tests represented by pairs ((Pi,Xi))1≤i≤m of p-values Pi and covariates Xi, such that Pi⊥Xi if Hi is null. Here, we show how to use information potentially available in the covariates about heterogeneities among…