Modeling Between-Study Heterogeneity for Improved Replicability in Gene Signature Selection and Clinical Prediction
建模研究间异质性以提高基因特征选择与临床预测的可重复性
In the genomic era, the identification of gene signatures associated with disease is of significant interest. Such signatures are often used to predict clinical outcomes in new patients and aid clinical decision-making. However, recent studies have shown that gene signatures are often not replicable. This occurrence has practical implications regarding the generalizability and clinical applicability of such signatures. To improve replicability, we introduce a novel approach…