论文检索

识别产气荚膜梭菌致病菌株间一致变化蛋白的定制多元混合模型AI 解读

Necrotic enteritis (NE) is a serious disease of poultry caused by the bacterium C. perfringens. To identify proteins of C. perfringens that confer virulence with respect to NE, the protein secretions of four NE disease-producing strains and one baseline nondisease-producing strain of C. perfringens were examined. The problem then becomes a clustering task, for the identification of two extreme groups of proteins that were produced at either concordantly higher or…

协变量缺失的 Cox 回归模型诊断度量AI 解读

-values of the goodness of fit statistics. Simulation studies are conducted to evaluate our methods, and a real data set is analyzed to illustrate their use.

研究内样本协方差矩阵部分缺失时的多元元回归贝叶斯推断AI 解读

Multivariate meta-regression models are commonly used in settings where the response variable is naturally multidimensional. Such settings are common in cardiovascular and diabetes studies where the goal is to study cholesterol levels once a certain medication is given. In this setting, the natural multivariate endpoint is low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides (TG) (LDL-C, HDL-C, TG). In this article, we…

二项回归模型中 Jeffreys 先验的性质与计算实现AI 解读

We study several theoretical properties of Jeffreys's prior for binomial regression models. We show that Jeffreys's prior is symmetric and unimodal for a class of binomial regression models. We characterize the tail behavior of Jeffreys's prior by comparing it with the multivariate t and normal distributions under the commonly used logistic, probit, and complementary log-log regression models. We also show that the prior and posterior normalizing constants under Jeffreys's…

Cox 回归模型的后验适定性与计算：缺失协变量应用AI 解读

In this paper, we carry out an in-depth theoretical investigation of Bayesian inference for the Cox regression model. We establish necessary and sufficient conditions for posterior propriety of the regression coefficient, β, in Cox's partial likelihood, which can be obtained as the limiting marginal posterior distribution of β through the specification of a gamma process prior for the cumulative baseline hazard and a uniform improper prior for β. We also examine necessary…

广义线性模型的缺失数据方法AI 解读

Missing data is a major issue in many applied problems, especially in the biomedical sciences. We review four common approaches for inference in generalized linear models (GLMs) with missing covariate data: maximum likelihood (ML), multiple imputation (MI), fully Bayesian (FB), and weighted estimating equations (WEEs). There is considerable interest in how these four methodologies are related, the properties of each approach, the advantages and disadvantages of each…

随机缺失协变量回归模型的后验正常化与极大似然估计存在性AI 解读

Characterizing model identifiability in the presence of missing covariate data is a very important issue in missing data problems. In this article, we characterize the propriety of the posterior distribution of the regression coefficients for some general classes of regression models, including the class of generalized linear models (GLM's) and parametric survival models with right-censored data. Toward this goal, we derive some very general and easy-to-check conditions for…

癌症预防研究中的生存数据模型AI 解读

Summary We propose a new parametric survival model for cancer prevention studies. The formulation of the model is in the spirit of stochastic modelling of the occurrences of tumours through two stages: initiation of an undetected tumour and promotion of the tumour to a detectable cancer. Several novel properties of the model proposed are derived. In addition, we examine the relationship of our model with the existing lagged regression model of Zucker and Lakatos. Also, we…

DNA 微阵列基因表达数据的贝叶斯模型AI 解读

Two of the critical issues that arise when examining DNA microarray data are (1) determination of which genes best discriminate among the different types of tissue, and (2) characterization of expression patterns in tumor tissues. For (1), there are many genes that characterize DNA expression, and it is of critical importance to try and identify a small set of genes that best discriminate between normal and tumor tissues. For (2), it is critical to be able to characterize…

二元响应数据的一类新偏斜链接模型AI 解读

The logit, probit, and student t-links are widely used in modeling dichotomous quantal response data. Most of the commonly used link functions are symmetric, except the complementary log-log link. However, in some applications the overall fit can be significantly improved by the use of an asymmetric link. In this article we propose a new skewed link model for analyzing binary response data with covariates. Introducing a skewed distribution for the underlying latent variable,…

含治愈比例生存数据的新贝叶斯模型AI 解读

We consider Bayesian methods for right-censored survival data for populations with a surviving (cure) fraction. We propose a model that is quite different from the standard mixture model for cure rates. We provide a natural motivation and interpretation of the model and derive several novel properties of it. First, we show that the model has a proportional hazards structure, with the covariates depending naturally on the cure rate. Second, we derive several properties of the…

Logistic 回归模型的先验 elicitation、变量选择与贝叶斯计算AI 解读

Summary Bayesian selection of variables is often difficult to carry out because of the challenge in specifying prior distributions for the regression parameters for all possible models, specifying a prior distribution on the model space and computations. We address these three issues for the logistic regression model. For the first, we propose an informative prior distribution for variable selection. Several theoretical and computational properties of the prior are derived…

缺失机制不可忽略时广义线性模型中的协变量缺失AI 解读

Summary We propose a method for estimating parameters in generalized linear models with missing covariates and a non-ignorable missing data mechanism. We use a multinomial model for the missing data indicators and propose a joint distribution for them which can be written as a sequence of one-dimensional conditional distributions, with each one-dimensional conditional distribution consisting of a logistic regression. We allow the covariates to be either categorical or…

利用历史对照调整二元数据趋势检验中的协变量AI 解读

Historical data often play an important role in helping interpret the results of a current study. This article is motivated primarily by one specific application: the analysis of data from rodent carcinogenicity studies. By proposing a suitable informative prior distribution on the relationship between control outcome data and covariates, we derive modified trend test statistics that incorporate historical control information to adjust for covariate effects. Frequentist and…

估计归一化常数比值的蒙特卡洛方法AI 解读

Recently, estimating ratios of normalizing constants has played an important role in Bayesian computations. Applications of estimating ratios of normalizing constants arise in many aspects of Bayesian statistical inference. In this article, we present an overview and discuss the current Monte Carlo methods for estimating ratios of normalizing constants. Then we propose a new ratio importance sampling method and establish its theoretical framework. We find that the ratio…

重要性加权的贝叶斯边际后验密度估计AI 解读

Markov chain sampling schemes generate dependent observations {Θi, 0 ≤ i ≤ n} from a full joint posterior distribution π(θdata). Frequently, only certain marginals of this full posterior density are of interest; thus an interesting problem is how to estimate the marginal posterior densities based on the dependent observations {Θi, 0 ≤ i ≤ n} from π(θ data). We propose a new importance-weighted marginal density estimation (IWMDE) method. An IWMDE is obtained by averaging many…