Mining Massive Amounts of Genomic Data: A Semiparametric Topic Modeling Approach
海量基因组数据挖掘：半参数主题建模方法
Characterizing the functional relevance of transcription factors (TFs) in different biological contexts is pivotal in systems biology. Given the massive amount of genomic data, computational identification of TFs is emerging as a useful approach to bridge functional genomics with disease risk loci. In this article, we use large-scale gene expression and chromatin immunoprecipitation (ChIP) data corpuses to conduct high-throughput TF-biological context association analysis.…