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线性样条模型中的结点估计AI 解读

The linear spline model is able to accommodate nonlinear effects while allowing for an easy interpretation. It has significant applications in studying threshold effects and change-points. However, its application in practice has been limited by the lack of both rigorously studied and computationally convenient method for estimating knots. A key difficulty in estimating knots lies in the nondifferentiability. In this article, we study influence functions of regular and…

纵向研究中基因与环境交互的集合检验AI 解读

We propose a generalized score type test for set-based inference for gene-environment interaction with longitudinally measured quantitative traits. The test is robust to misspecification of within subject correlation structure and has enhanced power compared to existing alternatives. Unlike tests for marginal genetic association, set-based tests for gene-environment interaction face the challenges of a potentially misspecified and high-dimensional main effect model under the…

两部分层级模型的贝叶斯推断AI 解读

Profiling is currently an important, and hotly debated, topic in health care and other industries looking for ways to control costs, increase profitability, and increase service quality. Managed care in particular has seen a proliferation in the use of statistical profiling methodology, particularly with regard to monitoring expenditure data. This article focuses on the specific problem of developing statistical methods appropriate for profiling physician contributions to…